Rui fentanyl fentanyl for postoperative mechanical ventilation in patients with chest pain Comparison of.docVIP

 PAGE \* MERGEFORMAT 4 Rui fentanyl fentanyl for postoperative mechanical ventilation in patients with chest pain Comparison of Surgical intensive care unit (SICU) of the patients often in need of appropriate analgesia and sedation, in particular, patients with intubation and mechanical ventilation, analgesia and sedation in patients with pain and discomfort caused by inadequate, anxiety, irritability, insomnia, and even mental disturbance of consciousness, it is difficult insertion tolerance tube, over-sedation was extended mechanical ventilation time and increased ventilator-associated pneumonia occurred, and critically ill patients for tracheal intubation and is conducive to effective analgesia and sedation in patients with respiratory management and to promote recovery [1]. New guidelines state that patients should first be considered for ICU analgesia and, if need to give sedation [2]. Fentanyl is commonly used in SICU patients with severe pain medicines, but easy to accumulate by liver metabolism by organ function. Midazolam, propofol is commonly used sedative drugs, but these drugs are often no analgesic effect, the patient lost consciousness while, but there is still pain, leading to high blood pressure, heart rate, sedation can lead to extension of the transitional time of mechanical ventilation. Remifentanil (REM) is a selective, short-acting μ-opioid receptor agonist, with the onset and rapidly eliminated, extrahepatic metabolism characteristics of [1]. In recent years, study table Mingrui fentanyl SICU in critically ill patients intubation and mechanical ventilation is not only a good analgesic effect, and on this basis, to remain calm state, has a good prospect for clinical application. First, critical patients in the pharmacokinetics of remifentanil Remifentanil for the 4 - methoxy-hydroxy-fentanyl susceptible to blood and tissue non-specific esterase in the hydrolysis, in vivo distribution of fast, dose-dependent m