Runx3 and gastric cancer Research.docVIP

 PAGE \* MERGEFORMAT 17 Runx3 and gastric cancer Research [Abstract] Objective To investigate the Runx3 tumor suppressor gene and the relationship between the occurrence and development of gastric cancer and their silencing in gastric cancer. Method in PubMed to retrieve and review the literature. Results Runx3 inactivation of tumor suppressor genes and the occurrence and development of gastric cancer is closely related to promoter methylation and excessive loss of heterozygosity is its primary mechanism of gene silencing. Conclusion is that gastric cancer diagnosis and treatment of cancer to provide new strategies and programs. [Keywords:] stomach neoplasms; tumor suppressor gene; Runx3 Runx3 (PEBP2α C/CBF A3/AML2) gene is a tumor suppressor gene, whose loss of function with a variety of malignant tumors related to the occurrence and development. Since 2002, Japanese scholar Li et al [1] first reported the adjustment Runx3 gastric epithelial cell proliferation and apoptosis in the role of balance since, Runx3 and gastric cancer occurrence and development of gastric cancer-related research has become a hot research field. Runx3 and gastric cancer is now right to do an overview of the status quo. 1 Runx3 gene, protein structure and function of Runx3 transcription factor from the Runt domain (Runt domain transcription factors), is the family of a member of the Runx transcription factors, Runt transcription factors, also known as the Regional PEBP2/CBF (polyomavirus enhancer-core binding protein 2/core binding factor), is the TGF - β superfamily signaling an important target goals, in mammals play an important role in the growth process. The gene family in mammals, there are three members of the Runx1, Runx2, Runx3, their products are composed of α and β subunit composition of heterodimers [2], with different biological function, Runx1 and hematopoietic function related, Runx2 is an important bone formation regulator, Runx3 pairs of spinal ganglion nerve d