Scopolamine and scopolamine methyl chlorpyrifos in rats on the impact of changes in body temperature changes with the tail of the relationship between heat.docVIP

 PAGE \* MERGEFORMAT 16 Scopolamine and scopolamine methyl chlorpyrifos in rats on the impact of changes in body temperature changes with the tail of the relationship between heat Author: LAI Yan Yong-Lu ZENG Jun Ren Jia [Abstract] Objective of this study was to explore the scopolamine and methyl scopolamine to organophosphate pesticide chlorpyrifos (CHP) caused by low-temperature effects and delayed fever response in the tail of heat and changes in relationships. Methods Using wireless telemetry recorded continuously 25 ℃ ambient temperature in the rat’s body core temperature, measured with digital thermometers tail skin temperature, each time interval 1h. In the CHP (25 mg / kg) in rats caused by low-temperature heating period and the delayed phase, respectively, to the peripheral cholinergic antagonist methyl-scopolamine (1mg/kg) and the central weeks cholinergic antagonist scopolamine (1mg/kg ). The results of chlorpyrifos led to rapid reduction of body temperature when accompanied by a marked increase in response to tail heat. Scopolamine could block the CHP, a cooling effect and blood vessel relaxation effects, but its role in methyl scopolamine had no significant effect. Methyl-scopolamine blocked CHP cocoa fever caused by the delay, while scopolamine could improve its mild fever. Conclusion The results prove that organophosphate insecticide chlorpyrifos caused by low temperature and blood vessel relaxation is mainly caused by central cholinergic pathway, while the fever response mainly through the peripheral cholinergic pathways caused. Experiments on human exposure to organophosphorus pesticides appear in the phenomenon of sustained fever and the use of atropine treatment provides a possible explanation for its treatment of fever with peripheral cholinergic antagonist methyl scopolamine effect of pH may be better. [Keywords:] organic phosphorus insecticides; low temperature; delayed fever; cholinergic blocking agent; tail skin temperature Abstra