Second cream-like skin toxicity test analysis.docVIP

 PAGE \* MERGEFORMAT 11 Second cream-like skin toxicity test analysis [Abstract] Objective To observe the second kind of ointment on the skin toxicity in rats and guinea pigs. Methods Wistar rats with acute skin toxicity, skin irritation with guinea pigs and skin allergy tests. Results cream coated with two large samples mice were not intact skin and damaged skin acute toxicity, skin irritation in guinea pigs and allergy. Conclusion II-like paste is safer topical agents can be applied in clinical practice. [Keywords:] Second, paste-like, acute toxicity, skin irritation, skin allergy Second, paste-like extract from the pain and cramp cream mixture, coated surface of the skin when using external use, mainly for the treatment of early sore in detoxification, swelling and pain and so a significant effect. We used Wistar rats, acute skin toxicity tests carried out on guinea pig skin irritation and skin allergy test to further validate the safety of the second kind of paste, the results reported below. 1 Test materials 1.1 with the test drugs Cramp cream: from Folium, frankincense, rhubarb, vitriol, gall, myrrh, berberine, Zhang Dan, hibiscus leaves, cork composition, with swelling and Sida, the role of pain Sanjie. Analgesic cream: from Fritillaria , Angelica, rhubarb, wide wood, water mint, camphor, borneol, musk composition, with swelling and relieve pain, removal of rotten tissue regeneration effect. II-like paste: cramp pain relief cream and cream with an equal amount the ratio of 1:1 honey mix as the test, the Affiliated Hospital of Gansu College of self. In another 120 g of honey as a reference substance. positive allergens: 2,4 - dinitrochlorobenzene, batch number 930806, Military Academy of medical supply station provided, configured with acetone concentration of 1.0% and 0.1% of allergens stimulate concentration. 1.2 Animals Healthy Wistar rats SPF 56 level, male and female, weighing 180 ~ 250 g; general level 98 guinea pigs, male an