Second trimester AFP and freehuman chorionic gonadotropin and umbilical artery blood flow and adverse pregnancy outcome.docVIP

 PAGE \* MERGEFORMAT 20 Second trimester AFP and freehuman chorionic gonadotropin and umbilical artery blood flow and adverse pregnancy outcome Of: Hou Hongying, Wang Linlin, Wu Lingling, Zhang Xinling, Huang Dongmei [Abstract] [Objective] To investigate the second trimester maternal serum markers and umbilical artery for predicting the clinical value of adverse pregnancy outcomes. [Method] The time-resolved fluorescence analysis of 876 cases from 14 to 21 weeks pregnant and pregnant women the second trimester alpha-fetoprotein (AFP), free human chorionic gonadotropin (free--hCG) testing; of which 536 cases of pregnant women 28 weeks pregnant 14 to detect the use of umbilical artery Doppler blood flow, and track their pregnancy outcome. Comparison with the Chi-square test elevated maternal serum markers (342 cases), abnormal umbilical artery (82 cases), elevated serum markers and abnormal umbilical artery (40 cases) between the adverse pregnancy outcomes rate difference. [Results] elevated maternal serum markers of adverse outcomes have preeclampsia, neonatal asphyxia, fetal growth restriction, fetal loss and placental abnormalities. these related incidence of adverse pregnancy outcomes in serum marker elevated group was 12.65%, abnormal blood flow in the umbilical artery was 8.5% in serum markers and abnormal umbilical artery flow both groups was 30.95%, compared with a significant difference between the two groups. [Conclusion] The increase in the second trimester maternal serum markers combined with abnormal umbilical artery flow, the occurrence of an increased risk of adverse pregnancy outcomes. [Keywords:] the second trimester; AFP; free human chorionic gonadotropin; umbilical artery; Doppler; adverse pregnancy outcomes Abstract: [Objective] To investigate the clinical value of second trimester maternal serum screening and umbilical artery Doppler for prediction of adverse pregnancy outcome. [Method] A total of 876 women were taken blood samp