Stromal cell-derived factor 1 and its receptor CXCR4 and the relationship between breast cancer.docVIP

 PAGE \* MERGEFORMAT 24 Stromal cell-derived factor 1 and its receptor CXCR4 and the relationship between breast cancer Keywords: breast cancer, stromal cell-derived factor  1 (SDF  1) CXCR4 Breast cancer is the harm women’s health, one of the major malignant tumors. In the worldwide incidence of breast cancer on the rise, it has been reported in the literature, European and American countries are about one for every 10 women who breast cancer. The prognosis of patients with breast cancer and tumor recurrence, metastasis, distant metastasis has become a constraint to improve the prognosis of patients with long-term survival and a major obstacle to [1]. Recent studies found that stromal cell-derived factor  1 (stromal cell  derived factor  1, SDF  1) and its receptor CXCR4 signaling pathway consisting of the directional spread of breast cancer cells and organ-specific metastasis. In this paper, SDF  1 and its receptor CXCR4 in structure, function and the relationship with breast cancer for a discussion. 1 SDF  1 and CXCR4 structure 1.1 SDF  1 1994 Nian Nagasawa et al [2] first in the P6 mice bone marrow stromal cells to secrete cytokines was found that an agent has a signal sequence features will initially be referred to as pre-B cell growth-stimulating factor (pre  B cell stimulatory factor, PBSF), then found that it is encoded as a 89 amino acid peptide, based on its amino acid sequence that would be classified in the CXC chemokine subfamily, named CXCL12. Since the factor derived from stromal cells, it also known as stromal cell-derived factor  1 (SDF  1). Crump et al [3] the use of nuclear magnetic resonance spectrum analysis and put forward the structural model of SDF  1 is a monomer form, is divided into SDF  1α and SDF  1β two subtypes, with the other CC or CXC class chemokine in the structure on only in the C  end and N  terminal amino acid residues are different. The 89 amino acid peptide of SDF  1α, and SDF 