Strychnos pharmacology and toxicology research review and safety research prospects.docVIP

 PAGE \* MERGEFORMAT 22 Strychnos pharmacology and toxicology research review and safety research prospects Author: Guo Zhenhua, Hong-Mei Ma, Zhang Boli [Keywords:] Strychnos; pharmacology; toxicology; Safety The 2005 edition of ‘Chinese Pharmacopoeia’ records, also known as bitter fact brucine, brucine, bitter taste, a big drug, which normally takes semen medicine belong to the liver, spleen; Strychnos function Sanjie swelling, pain Tongluo Chinese medicine attending Bi stubborn rheumatism, numbness, paralysis and bruises, and so on. Frequently used in clinical medicine, compound compatibility of applications, treat rheumatism and rheumatoid arthritis, stroke, hemiplegia, dementia, retinopathy, as well as orthopedic, surgical and other diseases, its clinical application for nearly a thousand years of history, has also been made for a very good clinical efficacy. But in recent years about the toxicity of Strychnos growing number of cases reported [1], affect the Strychnos and its safe use of the clinical medicine, and international access, therefore, an urgent need to carry out the Strychnos and medicine safety research to recognized at home and abroad to ensure the development of its quality and safety control standards. Strychnos contains many alkaloids [2,3], is currently recognized Strychnos toxic components are mainly strychnine (strychnine), and strychnine (brucine). In this paper, Strychnos progress over the past decade overview of pharmacology and toxicology studies and to propose in the future Strychnos safety research needed to solve problems. 1 Progress in pharmacological research 1.1 nervous system pharmacological effects Strychnos Alkaloids is the active ingredient is toxic ingredients, is the highest content of alkaloids strychnine and brucine. Strychnine as a whole has a central nervous system stimulant, first excited the spinal cord reflex function, followed by the excitement of the respiratory center and the medullary vasomotor center and