The promotion of fracture healing methods Recent research on.docVIP

 PAGE \* MERGEFORMAT 14 The promotion of fracture healing methods Recent research on Keywords:: fracture healing induced osteogenesis Fracture healing is an influential factor in a number of extremely complex biological process. In recent years, to explore methods and mechanisms for the promotion of fracture healing research has made remarkable progress. 1. Bone growth factors and induction of bone fracture healing by creeping substitution, or bone induction to complete there are differences over the years. Urist (1965) to demineralized bone implanted in muscle, successfully induced ectopic bone formation, and predicts that demineralized bone contains a special protein that can induce blood vessels around the migratory mesenchymal cells into bone lineage cells, The protein called bone morphogenetic protein (BMP). Subsequently in 1982, purified from the bone in the BMP (bBMP), and biochemical characteristics of the areas of in-depth research, thus elaborated a new theory of fracture healing - osteogenesis. Chalmers et al 〔 1〕 made osteoinduction three elements: (1)-induced irritant - BMP; (2) BMP target cells - mesenchymal type cells; (3) is conducive to bone growth and blood supply of the environment. Following Urist, after a number of animal bones from the people and organizations, purified BMP. Experimental results show that BMP normal bone tissue collagen fibers are mainly located in bone, periosteum and bone marrow stroma 〔 2〕 . BMP is also present in mice and human osteosarcoma, chondrosarcoma, but are not measured in the presence of BMP 〔 3〕 . Clinical Application of BMP to repair bone defects has reported a successful 〔 4,5〕 . BMP concentration in bone, however, is minimal, about 1mg/kg wet bone, and the rapid dispersion in the body, the degradation 〔 6〕 , so only use BMP to repair bone defects too 〔 4〕 , so that clinical application is limited. How to get the smallest amount of a larger BMP osteogenic effect, become issues of concern 〔 7〕 . In recen