Traditional Chinese Medicine anti-oxidative damage of Alzheimer#39;s disease prevention and control.docVIP

 PAGE \* MERGEFORMAT 17 Traditional Chinese Medicine anti-oxidative damage of Alzheimer#39;s disease prevention and control Abstract aspects of oxidative damage from the brief description of the occurrence and development of Aβ in the AD pathogenic role in the process, examples of traditional Chinese medicine and its extract single herb medicine, Chinese herbal compound’s role in the anti-oxidative damage significant and deserves further research. Keywords: oxidative damage; Alzheimer’s disease; β-amyloid protein Alzheimer’s disease occurred in the period of pre-elderly and elderly with progressive memory impaired and affect the life and social skills, characterized by progressive degenerative brain disease. Is also the most common type of senile dementia, one of morbidity and high mortality. Modern medical prevention and treatment of this disease has yet to make any breakthroughs. In recent years, Chinese medicine prevention and treatment of Alzheimer’s disease research has made encouraging progress, has aroused the concern of the medical profession at home and abroad. 1 β-amyloid protein and free radicals Aβ can be induced by a number of ways to ROS generation: (1) Aβ oligomers and metal ions of (Fe2, Cu2) with, through the Fenton reaction, can be obtained from the peroxides such as H2O2 hydroxyl radical; (2) Aβ with nerve cells and glial cell membrane receptor for advanced glycation end products (receptor specific for advanted glycosylation end products, RAGE), thereby causing the downstream activation of NADH oxidase to produce ROS [1]. Some scholars believe that the role of Aβ directly NADHP cytochrome P450, as the latter is caused by the abnormal substrate oxygen stress; (3) indirect effect: Aβ-induced local immune response, producing inflammatory cytokines, thereby forming an oxygen stress micro-environment; (4) Aβ precursor APP in the cell may also play a role in the oxidation process. Because APP has the structure