Vinorelbine due to progress in prevention and treatment of phlebitis.docVIP

 PAGE \* MERGEFORMAT 24 Vinorelbine due to progress in prevention and treatment of phlebitis [Keywords:] Prevention of vinorelbine phlebitis Vinorelbine as broad-spectrum agents, is semi-synthetic derivatives of vinblastine, the tumor cells in G1 phase and M phase, is a cell cycle specific drugs for breast cancer, non-small cell carcinoma, malignant lymphoma good effect However, vinorelbine is a strong stimulus blistering drug, on blood vessels have a strong irritant and injury. the literature [1] After intravenous injection of vinorelbine phlebitis rate of the local 57.6%, not only to pain patients, and the chemotherapy can not proceed smoothly, delay in treatment. In this paper, in recent years to prevent, treat phlebitis vinorelbine methods were reviewed. Phlebitis caused by factors 1 1.1 Drug factors Vinorelbine are cytotoxic agents, can cause allergic vasculitis, and its basic formulations of carbon dioxide can accumulate in blood vessels, increased blood pressure and increased vessel wall permeability, liquid permeability and into the subcutaneous space wall bleeding, lead to changes in local pH value, veins and capillaries cramps, reduced blood supply, local tissue ischemia and hypoxia, and then necrosis, blisters, induration, and ulceration. other drugs can penetrate the skin directly stimulate the nerve endings, causing the patient sustained, significant local pain. This drug is mainly administered intravenously, requiring 15 ~ 30min rapid infusion, further enhanced the stimulation of blood vessels. 1.2 mechanical injury Puncture unskilled, a puncture or repeated unsuccessful puncture site in the same vessel, resulting in more parts of vascular injuries, puncture needle pierced the vessel wall of drug extravasation, or bevel needle hole is not fully enter the bloodstream, drug leakage to the extravascular , the puncture needle fixation is not strong, emerge from the blood vessels caused by liquid leakage, pull out the needle, the e