Viral drug treatment in children.docVIP

 PAGE \* MERGEFORMAT 19 Viral drug treatment in children [Keywords:] pediatric viral drug treatment Viral disease is the world’s highest incidence of the disease, its spread is strong, serious threat to human beings, especially children’s health and lives. As the 20th century, 80 years of the AIDS (AIDS), 2003 years when the global panic caused by the atypical pneumonia (SARS) and the current emerging avian flu, have a high degree of transmission, high mortality rate and there is no effective treatment of drug characteristics. Therefore, the study of antiviral drugs has become a hot topic in today’s international research. 1 Classification of antiviral drugs 1.1 Classification by structure (1) tricyclic amines: amantadine, rimantadine, etc.; (2) pyrophosphate categories: phosphonic acid, etc.; (3) protease inhibitor (peptide like material): Sand Saquinavir, ritonavir, indole ritonavir, nelfinavir, etc.; (4), nucleoside analogue drugs: acyclovir, lamivudine, ribavirin, zidovudine, etc.; (5) Other: delavirdine, Glycyrrhizin, interferon, nevirapine, as well as antisense oligonucleotides and so on. 1.2 according to the role of classification (1) anti-human immunodeficiency virus (HIV) drugs: indole ritonavir, nelfinavir, delavirdine, NVP equality; (2) anti-CMV drugs: foscarnet sodium, ganciclovir, etc.; ( 3) anti-hepatitis B virus drugs: interferon and Ara-AMP, lamivudine, glycyrrhizin, etc.; (4) anti-herpes virus drugs: aciclovir, valaciclovir, famciclovir, Ara, etc.; (5) Anti-influenza and respiratory viral drugs: amantadine, rimantadine, ribavirin, antisense oligonucleotides etc.. 2 The role of the various features of antiviral drugs 2.1 Chemical Drug Nucleoside drugs 2.1.1 (1) of ribavirin (Ribavirin, Ribavirin): are broad-spectrum antiviral drugs, inhibit a variety of DNA and RNA virus nucleic acid synthesis, preventing viral replication. It A, influenza B virus (Influ), parainfluenza Have a certain effect [1,2,3]. General dosage is a daily 10 ~ 15