Vitamin D3 analogues in treating psoriasis of the new progress.docVIP

 PAGE \* MERGEFORMAT 19 Vitamin D3 analogues in treating psoriasis of the new progress Abstract: Over the past 10 years, the vitamin D3 analogues topical treatment of psoriasis has led to change. This ligand - receptor gene transcription by the mode of action of vitamin D3 response element in their promoter region to achieve regulation of gene transcription. Vitamin D3 analogues inhibit a variety of skin inflammation and epidermal proliferation are conducive to enhancing the normal keratinization. Has proven in vivo activation of vitamin D3 analogues have a reliable anti-psoriatic effect. The calcipotriol and other vitamin D3 analogues and their objective control study its anti-psoriasis therapy combined with a lot of information. Conclusion: Calcipotriol is a first-line treatment of psoriasis, joint several other anti-psoriasis drugs such as topical corticosteroids, PUVA, cyclosporine, and Avi, etc. A better effect. More than 50 years ago, Reed and other vitamin D analogues have been reported effective treatment of psoriasis, after the high blood calcium due to concerns about side effects, so that the compound failed to further development of the authors in 1985 reported that with the lα-hydroxy vitamin D3 treatment osteomalacia, the patient’s psoriasis can be improved, since a variety of vitamin D3 analogues (VDAs) have been developed for the treatment of psoriasis. The overall effect of cell biology Vitamin D3 by lα and 25-bit Hydroxylation has been activated, activation of vitamin D3 derivatives acting on the gut, bone and kidney, by increasing the intestinal absorption of calcium and promote kidney recovery of calcium and bone calcium mobilization to increase serum calcium concentration, VDAs addition to the role of vitamin D3 in response to these typical organ, the do not act on almost all types of cells, including epidermal cells, fibroblasts and bone marrow-derived cells. Activated nuclear receptor