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Complete genome sequence of a Megalocytivirus (family Iridoviridae) associated with turbot mortality in China.doc

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Complete genome sequence of a Megalocytivirus (family Iridoviridae) associated with turbot mortality in China

Shi et al. Virology Journal 2010, 7:159 /content/7/1/159 RESEARCH Open Access ResearchComplete genome sequence of a Megalocytivirus (family Iridoviridae) associated with turbot mortality in China Cheng-Yin Shi1, Kun-Tong Jia1,2, Bing Yang1 and Jie Huang*1 Abstract Background: Turbot reddish body iridovirus (TRBIV) causes serious systemic diseases with high mortality in the cultured turbot, Scophthalmus maximus. We here sequenced and analyzed the complete genome of TRBIV, which was identified in Shandong province, China. Results: The genome of TRBIV is a linear double-stranded DNA of 110,104 base pairs, comprising 55% G + C. Total 115 open reading frames were identified, encoding polypeptides ranging from 40 to 1168 amino acids. Amino acid sequences analysis revealed that 39 of the 115 potential gene products of TRBIV show significant homology to other iridovirus proteins. Phylogenetic analysis of conserved genes indicated that TRBIV is closely related to infectious spleen and kidney necrosis virus (ISKNV), rock bream iridovirus (RBIV), orange-spotted grouper iridovirus (OSGIV), and large yellow croaker iridovirus (LYCIV). The results indicated that TRBIV belongs to the genus Megalocytivirus (family Iridoviridae). Conclusions: The determination of the genome of TRBIV will provide useful information for comparative study of Megalocytivirus and developing strategies to control outbreaks of TRBIV-induced disease. Background rus; tiger frog virus (TFV), frog virus 3 (FV-3), Ambys- toma tigrinum virus (ATV), and Singapore grouper iridovirus (SGIV) of the genus Ranavirus; infectious Iridoviruses are large, icosahedral, double-stranded DNA (dsDNA) viruses that can infect invertebrates and poiki- lothermic vertebrates, including insects, fish, amphibi- spleen and kidney necrosis virus (ISKNV), orange-spot- ans, and reptiles. The viral genomes are both circularly ted grouper iridovirus (OSGIV), rock bream iridoviru