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Confined Placental Mosaicism and Intrauterine Growth Retardation.doc

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Confined Placental Mosaicism and Intrauterine Growth Retardation

Derleme / Review 109 DOI: 10.5472/MMJ.2012.02457.1 Plasentaya S?n?rl? Mozaiklik ve ?ntrauterin Geli?me Gerili?i Confined Placental Mosaicism and Intrauterine Growth Retardation Aytül ?ORBACIO?LU ESMER Kad?n Hastal?klar? ve Do?um Anabilim Dal?, ?stanbul T?p Fakültesi, ?stanbul üniversitesi, ?stanbul, Türkiye ?zet Abstract Plasentaya s?n?rl? mozaiklik, karyotipi normal olan bir fetusa ait plasentada kromozomu anormal olan bir hücre dizisinin var olmas?d?r. Koryon villus ?rneklemesinde hem normal hem de an?ploid hücre dizisi saptan?rken, fetal kan veya amniyon s?v?s? incelemelerinde sadece normal hücre dizisinin bulunmas? ile tan? konur. Uniparental dizomi ise bir homolog kromozom ?iftinin her ikisinin Confined placental mosaicism is the presence of an abnormal cell line in the placenta of a fetus having a normal karyotype. It is diagnosed by the detection of both normal and abnormal cell lines in samples of chorionic villi, while only the normal cell line is detected in fetal blood samples and by amniocentesis. Uniparental disomy refers to the transmission of both members of a ayn? ebevenyden gelmesine verilen isimdir ve plasentaya s?n?rl? mozaiklik ile homologous chromosome pair from the same parent and can be present together with confined placental mosacisim. The prevalence of confined s?n?rl? mozaiklik prevalans? %15,7 ile %25 aras?nda de?i?mektedir. Plasentaya placental mosaicism in the population of idiopatic intrauterine growth birlikte g?rülebilir. ?diyopatik intrauterin geli?me gerili?i olgular?nda plasentaya s?n?rl? mozaiklik ayn? zamanda oligohidramniyos, spontan abortus ve fetal kay?p ile de ili?kilendirilmi?tir. ?ntrauterin geli?me gerili?i en s?k 2,7,15 ve 16 numaral? kromozomlarda g?rülen plasentaya s?n?rl? mozaiklik olgular?nda ve 7,11,14, 15 retardation varies between 15.7% and 25%. Confined placental mosaicism is also associated with oligohydramnios, spontaneous abortion and fe