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Converting a breast cancer microarray signature into a high-throughput diagnostic test.doc

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Converting a breast cancer microarray signature into a high-throughput diagnostic test

BMC Genomics BioMedCentral Methodology article Open Access Converting a breast cancer microarray signature into a high-throughput diagnostic test Annuska M Glas*1, Arno Floore1, Leonie JMJ Delahaye1, Anke T Witteveen1, Rob CF Pover1, Niels Bakx1, Jaana ST Lahti-Domenici1, Tako J Bruinsma1, Marc O Warmoes1, René Bernards1, Lodewyk FA Wessels2 and Laura J Van t Veer1 Address: 1Agendia BV, Slotervaart Medical Center 9D, Louwesweg 6, 1066 EC Amsterdam, The Netherlands and 2Netherlands Cancer Institute, department of Molecular Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands Email: Annuska M Glas* - annuska.glas@; Arno Floore - arno.floore@; Leonie JMJ Delahaye - Leonie.delahaye@; Anke T Witteveen - anke.witteveen@; Rob CF Pover - rob.pover@; Niels Bakx - niels.bakx@; Jaana ST Lahti-Domenici - jaana.lahti@; Tako J Bruinsma - tako.bruinsma@; Marc O Warmoes - marc.warmoes@; René Bernards - r.bernards@nki.nl; Lodewyk FA Wessels - l.wessels@nki.nl; Laura J Van t Veer - l.vt.veer@nki.nl * Corresponding author Published: 30 October 2006 Received: 24 May 2006 Accepted: 30 October 2006 BMC Genomics 2006, 7:278 doi:10.1186/1471-2164-7-278 This article is available from: /1471-2164/7/278 ? 2006 Glas et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: A 70-gene tumor expression profile was established as a powerful predictor of disease outcome in young breast cancer patients. This profile, however, was generated on microarrays containing 25,000 60-mer oligonucleotides that are not designed for processing of many samples on a routine basis. Results: To facilitate its use in a diagnostic setting, the 70-gene prognosis profile was translated into a customized microarray (