Barrier, Adsorptive, and Mechanical Properties of Containers Molded from PETPP Blends for Use in Pharmaceutical Solutions.docVIP

Materials Sciences and Applications, 2013, 4, 589-594 589 /10.4236/msa.2013.410072 Published Online October 2013 (/journal/msa) Barrier, Adsorptive, and Mechanical Properties of Containers Molded from PET/PP Blends for Use in Pharmaceutical Solutions Tadashi Otsuka , Ayako Kurosawa , Masaki Maeda , Kazushi Yamada , Masuo Murakami , 1 1 1 2 2 2 Hiroyuki Hamada 1 Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan; Department of Advanced 2 Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan. Email: tadashi-ootsuka@senju.co.jp Received August 5 , 2013; revised September 9 , 2013; accepted September 21 , 2013 th th st Copyright ? 2013 Tadashi Otsuka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT In this study, the adsorptive properties of L-menthol, moisture vapor transmission rate, and mechanical properties of poly (ethylene terephthalate) (PET), polypropylene (PP), and their blends were evaluated in containers fabricated by injection molding without a compatibilizing agent. These containers intended to hold pharmaceutical solutions contain- ing lipophilic chemicals such as L-menthol. By the addition of a small amount of PP, the moisture barrier properties of PET were effectively improved, but its anti-adsorptive property was reduced. The strength of the PET/PP blends was reduced, but some PET/PP blends were still able to bear the experimental load required for application