Chondrocalcinosis of Femoro-Tibial and Proximal Tibio-Fibular Joints in Cadaveric Specimens A High-Resolution CT Imaging Study of the Calcication Distribution.docVIP

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Chondrocalcinosis of Femoro-Tibial and Proximal Tibio-Fibular Joints in Cadaveric Specimens A High-Resolution CT Imaging Study of the Calcication Distribution.doc

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Chondrocalcinosis of Femoro-Tibial and Proximal Tibio-Fibular Joints in Cadaveric Specimens A High-Resolution CT Imaging Study of the Calcication Distribution

ChondrocalcinosisofFemoro-TibialandProximalTibio- FibularJointsinCadavericSpecimens:AHigh-Resolution CTImagingStudyoftheCalcificationDistribution Se′bastienTouraine1*,HangKorngEa2,Vale′rieBousson1,MartineCohen-Solal2,LiessLaouisset1, ChristineChappard1,Fre′de′ricLiote′2,Jean-DenisLaredo1 1Radiologie Oste′o-articulaire, Ho?pital Lariboisie`re, CNRS-UMR 7052, Laboratoire B2OA, Universite′ Paris-Diderot, Sorbonne Paris Cite′, Paris, France, 2Rhumatologie, Ho?pitalLariboisie`re,Inserm-UMR606,Universite′ ParisDiderot,SorbonneParisCite′,Paris,France Abstract Objectives:Toanalyzecalciumdepositsbycomputedtomography(CT)infemoro-tibialcompartmentsandproximaltibio- fibularjoints;toassesstherelationshipwithCT-assessedosteoarthritis(OA). Methods:68(34pairs)cadavericknees(meanageof84)werescannedathighresolutionCT.Menisciandhyalinecartilage calcificationsinthefemoro-tibialandproximaltibio-fibularjointswereanalyzed.OAwasCT-assessedbytheKellgrenand Lawrence score. Gross appearance of OA was evaluated on 29 left knees after dissection and India ink staining of tibial plateaus. Results: In femoro-tibial joints, meniscal calcifications (MC) and hyaline cartilage calcifications (HCC) were detected in 23(34%) and 14(21%) knees respectively. Calcifications mainly involved the three meniscal segments and were mainly observed in all thirds of the femoro-tibial compartments. In proximal tibio-fibular joints, HCC were detected in 19(28%) knees.TheassociationHCC-MCinfemoro-tibialjointsandbetweencalcificationsinfemoro-tibialandproximaltibio-fibular jointswasstrong(p,0.0001).Femoro-tibialandproximaltibio-fibularCT-assessedOAwererespectivelyfoundin23(34%) and 19(28%) knees. HCC were significantly associated with femoro-tibial OA (p=0.04) while MC were not (p=0.34). OA macroscopicevaluationshowedameansurfaceofcartilagelesionsof35%(range0.13–0.55).Nosignificantdifferencewas demonstratedregardingtheCT-detectionofMC,HCCorCT-assessedOA. Conclusions: This is the first study to report a strong assoc