Cholestane-3β, 5α, 6β-triol Suppresses Proleration, Migration, and Invasion of Human Prostate Cancer Cells.docVIP

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Cholestane-3β, 5α, 6β-triol Suppresses Proleration, Migration, and Invasion of Human Prostate Cancer Cells.doc

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Cholestane-3β, 5α, 6β-triol Suppresses Proleration, Migration, and Invasion of Human Prostate Cancer Cells

Cholestane-3b,5a,6b-triolSuppressesProliferation, Migration,andInvasionofHumanProstateCancerCells Ching-YuLin1,2,3.,ChiehHuo1,2,4.,Li-KuoKuo5.,RichardA.Hiipakka6,RichardBakerJones6,7 ,Hui- PingLin1,2,YuwenHung1,8,Liang-ChengSu1,2,Jen-ChihTseng1,8,Ying-YuKuo1,2,Yu-LingWang1,9 YasuhisaFukui1,Yung-HsiKao4,JohnM.Kokontis6,Chien-ChihYeh10,11,LinyiChen9,Shiaw-DerYang8, Hsiao-HuiFu8,Ya-WenChen2,3,KelvinK.C.Tsai2,3,Jang-YangChang2,3,Chih-PinChuu1,2,12,13 , * 1InstituteofCellularandSystemMedicine,NationalHealthResearchInstitutes,Miaoli,Taiwan,2TranslationalCenterforGlandularMalignancies,NationalHealthResearch Institutes, Miaoli, Taiwan, 3National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan, 4Department of Life Sciences, National Central University,Taoyuan,Taiwan,5DivisionofPulmonaryandCriticalCareMedicine,DepartmentofInternalMedicine,MackayMemorialHospital,Taipei,Taiwan,6BenMay DepartmentforCancerResearch,TheUniversityofChicago,Illinois,UnitedStatesofAmerica,7InstituteforGenomicsandSystemsBiology,TheUniversityofChicago, Illinois,UnitedStatesofAmerica,8InstituteofMolecularandCellularBiology,NationalTsingHuaUniversity,Hsinchu,Taiwan,9InstituteofMolecularMedicine,National TsingHuaUniversity,Hsinchu,Taiwan,10DivisionofColonandRectalSurgery,TaoyuanArmedForcesGeneralHospital,Taoyuan,Taiwan,11DepartmentofSurgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, 12Graduate Program for Aging, China Medical University, Taichung, Taiwan, 13Ph.D. Program in Tissue EngineeringandRegenerativeMedicine,NationalChungHsingUniversity,Taichung,Taiwan Abstract Oxysterols are oxidation products of cholesterol. Cholestane-3b, 5a, 6b-triol (abbreviated as triol) is one of the most abundantandactiveoxysterols.Here,wereportthattriolexhibitsanti-canceractivityagainsthumanprostatecancercells. Treatment of cells with triol dose-dependently suppressed proliferation of LNCaP CDXR-3, DU-145, and PC-3 human prostate cancer cells and reduced colony formation in