亚胺培南西司他丁钠与美罗培南治疗重症感染的成本-效果分析.pdfVIP

中国综合临床2013 年4 月第29 卷第4 期 Clinical Medicine of China. April 2013 .Vol 29 •Nι4 .387. ·论著· 亚胶培南/西司他丁纳与美罗培南 治疗重症感染的成本-效果分析 王秀琴柯森方张春柳 [摘要1 目的评价亚胶培南/西司他丁嗣(IMP) 与美罗培南(MEP) 治疗重症感染的经济学效果。 方法 运用最小成本分析法，分别对上述2 种治疗方案治疗重症感染的临床效果及成本进行评价。结果 亚胶培南/西司他丁铀组和美罗培南组治疗重症感染的总有效率分别为93. 33% (28/30) 和 85.71% (24/28) ，差异元统计学意义(χ2 =4. 89 ,P =0. 08);戚本·效果比(ClE) 分别为40.35 和71. 69 ，与亚肢培 南/西司他丁铀组相比，美罗培南组每增加一个单位效果需多花费( !J. CI !J.E)312. 16 元。结论 亚胶培 南/西司他丁铀组的成本，效果比优于美罗培南组，亚胶培南/西司他丁铀治疗重症感染有明显的药物经 济学优势。 【关键词】 亚腊培南/西司他丁铀; 美罗培南; 重症感染; 戚本-效果分析 Cωt-eftectiveo酬 analy函。0 Imipeoem-CiIasta伽 Sodium and Meropeoem for severe inf创tioo 阳NG Xiu-q切， KE Sen弗略 ， ZHANG Chun-liu. Pharmacy Department , the Mα 263 Genal Hosp阳l (扩 Be拼ng Military Region ， Be拚喀 101149 ， China Corresponding aωhoT:Z剧NG Chun-liu ， ETTULil:lizh阴暗1971@126. com 【 AbstI叫 0均创刊 To evaluate 由e economic effects of lmipene卧Cilastatin Sodium 四d Meropenem for severe infectio且 Metb创Is The therapeutic effects and costs of the two therapeutic schemes for severe infection were evaluated by using cost-minimization 缸uùysis. K倒:IIts 咀le total effective rates of lmipenem- cilastatin group and Meropenem group in the treatment severe infection were 93. 33% (28/30) and 85. 71 % ( 24/28) ,the difference were not statistically sign迫cant (矿= 4. 89 ,P = O. 082) . The cost-effectiveness ratio (ClE) were 40.35 and 7 1. 69 respectively. 咀e c晒t of every unit increment of effectiveness for. Meropenem group were 312.16 Yu皿，more 曲曲曲at of 由e Imipenem-cilastatin 伊oup.C幅clu曲0 Cost-effec由eness ratio of lmipenem-cilastatin is superior to 也at of Meropenem ,and lmipenem-cilastatin has obvious pharmacoeconomics advantage over Meropenem for severe infections. [陶 words ) lmipenem / cilastatin sodium; 蜘ropenem; Severe infection; Cωt-efectiveness analysis 从危重病急救医学角度讲，威胁生命的感染为