Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against Salmonella gallinarum英文文献资料.docVIP

Vol.4, No.9, 675-678 (2012) Health /10.4236/health.2012.49106 Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against Salmonella gallinarum Maduike C. O. Ezeibe , George N. Anosa, Okechi K. Okorie, Nnenna P. Elendu-Eleke, * Obianuju N. Okoroafor, Augustine A. Ngene, Ogechukwu N. Chikelu * Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria; Corresponding Author: maduikeezeibe@ Received 14 June 2012; revised 13 July 2012; accepted 25 July 2012 ABSTRACT lic health and as a cause of loss of investment to live- stock farmers and to meat processing factories [4]. Development of resistance by bactria to antibiotics of- ten results if the antibiotics fail to ellinate the bacterial infections [5]. For Ampicillin, its antibacterial activity depends on its bioavailability and on length of time it is able to maintain high concentration in blood of treated animals [6]. Differences in therapeutic actions of drugs made from same medicinal active ingredients but manu- factured by different companies are reported to be due to interactions of components used in formulating the drugs and on stabilizing agents used [7]. Alluminium-Magnesium Silicate (AMS) is used as a stabilizing agent for drugs used for treatment of diseases of man and of animals [8,9]. It is safe for use even on food animals [10] and was also decleared safe in a recent assessment that involved topical and oral administration to laboratory animals [11]. Its molecules have one of their ends positively charged and the other negatively charged [9]. These electrical charges make AMS, when in solution, to hydrate to form three dimentional coloidal structures which stabilize drugs’ active ingredients [9]. To stabilize means to protect against destruction. So,if AMS is used to make a formulation of Ampicillin tri- hydrate (AT), it may protect the antibiotic from being r