Antidepressant-Like Activity of Tetramethylpyrazine Measured by Chronic Experimental Method in Rat Model of Depression英文文献资料.docVIP

Pharmacology Pharmacy, 2012, 3, 52-57 /10.4236/pp.2012.31008 Published Online January 2012 (http://www.SciRP.org/journal/pp) Antidepressant-Like Activity of Tetramethylpyrazine Measured by Chronic Experimental Method in Rat Model of Depression Lijian Yu , Xiaodan Jiang , Yongping Zhang , Mingneng Liao , Rundi Ma , Tingxi Yu 1,2*# 1 1 1 1,2# 1,2,3*# 1 Laboratory of Marine Materia Medica, Guangdong Ocean University, Zhanjiang, China; 2 Depu Biomedical Technology Co., Ltd, Foshan, China; 3 Cell Biology Group, Department of Surgery, Department of Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, USA. * * Email: ywyj9578@, yutingxi@ Received October 4 , 2011; revised November 14 , 2011; accepted December 9 , 2011. th th th ABSTRACT The aim of this study was to investigate the potential antidepressive-like effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, in chronic mild stress (CMS)-induced rat model of depression. Male Sprague-Dawley (SD) strain rats were divided into six matched groups (n = 14 in each group) based on their sucrose consumption: control, CMS, CMS + fluoxetine (FLU), and CMS + TMP groups. The rats except control were housed separately in different rooms, and the rat model of depression was estab- lished by exposing to an unpredictable sequence of stressors for 28 days; the rats in CMS + FLU were exposed to CMS and received administration of FLU (2.0 mg/kg/d, ig) for 28 days; the rats in