Antidepressant-Like Effect of Tetramethylpyrazine in Mice and Rats英文文献资料.docVIP

Neuroscience Medicine, 2011, 2, 142-148 doi:10.4236/nm.2011.22020 Published Online June 2011 (http://www.SciRP.org/journal/nm) Antidepressant-Like Effect of Tetramethylpyrazine in Mice and Rats Lijian Yu , Xiaodan Jiang , Mingneng Liao , Rundi Ma , Tingxi Yu 1#* 1 1 1# 1,2#* 1 Key Laboratory of Marine Materia Medica, Guangdong Ocean University, Zhanjiang, China; Cell Biology Group, Department of 2 Surgery, Department of Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, USA. Email: ywyj9578@, yutingxi@ Received February 23 , 2011; revised April 6 , 2011; accepted April 20 , 2011. rd th th ABSTRACT The aim of this study was to investigate the potential antidepressive-like effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, and its mechanism of the antidepressant-like action. Forced-swimming, tail-suspension, reserpine-induced hypothermia, akinesia and ptosis, 5-hydroxytryptophan (5-HTP)-induced head-twitch, and potentiation of noradrenaline (NE) toxicity tests, were per- formed to assess the potential antidepressant-like activity of TMP and to study the mechanism by which TMP exerts the antidepressant-like action. Intragastric (ig) administration of TMP markedly reduced the duration of immobility during forced-swimming tests and tail-supension test in rats and mice. TMP partialy reversed reserpine-induced hypothermia, ptosis and akinesia, and potentiated NE toxicity in mice, and these are similar to those of clomipramine; however, TMP did not potentiate 5-HTP-induced head-twitch response (HTR) in mice, and this is