Antimicrobial Activity of Minocycline-Loaded Genipin-Crosslinked Nano-Fibrous Chitosan Mats for Guided Tissue Regeneration英文文献资料.docVIP

Journal of Biomaterials and Nanobiotechnology, 2012, 3, 528-532 /10.4236/jbnb.2012.324054 Published Online October 2012 (http://www.SciRP.org/journal/jbnb) Antimicrobial Activity of Minocycline-Loaded Genipin-Crosslinked Nano-Fibrous Chitosan Mats for Guided Tissue Regeneration Peter A. Norowski , Jegdish Babu , Pradeep C. Adatrow , Franklin Garcia-Godoy , 1 2 3 2 1 1 Warren O. Haggard , Joel D. Bumgardner 1 Department of Biomedical Engineering, Herff College of Engineering, University of Memphis, Memphis, USA; 2 Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, USA; dontology, College of Dentistry, University of Tennessee Health Science Center, Memphis, USA. Email: jbmgrdnr@ 3 Department of Perio- Received August 8 , 2012; revised September 17 , 2012; accepted September 27 , 2012 th th th ABSTRACT Antimicrobial delivery has been advocated for guided tissue regeneration (GTR) or guided bone regeneration (GBR) therapies involving patients with aggressive or unresolved periodontitis/peri-implantitis. Electrospun chitosan mem- branes demonstrate several advantages over traditional GTR barrier membranes because they stimulate healing, mimic the topology of the extracellular matrix, and allow for diffusion of nutrients and wastes into/out of the graft site, and were shown to stimulate bone formation in a rabbit calvarial critical-size defect model. Previously, we have shown im- provements in mechanical properties and degradation kinetics by crosslinking electrospun membranes with 5 mM or 10 mM genipin. We have