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Antimicrobial Peptides in Gastrointestinal Inflammation英文文献资料
SAGE-HindawiAccesstoResearch
InternationalJournalofIn?ammation
Volume2010,ArticleID910283,11pages
doi:10.4061/2010/910283
ReviewArticle
AntimicrobialPeptidesinGastrointestinalIn?ammation
SimonJ¨ager,EduardF.Stange,andJanWehkamp
DepartmentofInternalMedicineI,RobertBoschHospital,Dr.MargareteFischer-Bosch-InstituteofClinicalPharmacology,
Auerbachstr.112,70376Stuttgart,Germany
CorrespondenceshouldbeaddressedtoJanWehkamp,jan.wehkamp@ikp-stuttgart.de
Received28July2010;Accepted18August2010
AcademicEditor:G.Rogler
Copyright?2010SimonJ¨ageretal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,
whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
Acuteandchronicin?ammationsofmucosalsurfacesarecomplexeventsinwhichthee?ectormechanismsofinnateandadaptive
immunesystemsinteractwithpathogenicandcommensalbacteria.Theroleofconstitutiveandinducibleantimicrobialpeptides
inintestinalin?ammationhasbeeninvestigatedthoroughlyovertherecentyears,andtheirinvolvementinvariousdiseasestates
isexpandedevermore.Especiallyintheintestines,acriticalbalancebetweenluminalbacteriaandtheantimicrobialpeptidesis
essential,andabreakdowninbarrierfunctionbyimpairedproductionofdefensinsisalreadyimplicatedinCrohn’sdisease.Inthis
paper,wefocusontheroleofantimicrobialpeptidesinin?ammatoryprocessesalongthegastrointestinaltract,whileconsidering
theresidentandpathogenic?oraencounteredatthespeci?csites.Theroleofantimicrobialpeptidesintheprimaryeventsof
in?ammatoryboweldiseasesreceivesspecialattention.
1.Introduction
Recentyearshaveseenasteadilyrisinginterestinantimi-
crobialpeptides,andtheirimplicationinthepathogenesis
ofintestinalprocesseslikeCrohn’sdisease[2]ornecrotizing
enterocolitis[3]aswellastheirroleinpsoriasisandatopic
dermatitis,cystic?brosisandotitismediahasgarneredthe
attentionofanincreasinggroupofscientists.
In this paper, we would like to focus on the role of
antimicrobialpeptidesinin?ammatoryprocessesalongthe
gastroin
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