Antioxidant Mechanism is Involved in the Gastroprotective Effects of Ozonized Sunflower Oil in Ethanol-Induced Ulcers in Rats英文文献资料.docVIP

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Antioxidant Mechanism is Involved in the Gastroprotective Effects of Ozonized Sunflower Oil in Ethanol-Induced Ulcers in Rats英文文献资料.doc

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Antioxidant Mechanism is Involved in the Gastroprotective Effects of Ozonized Sunflower Oil in Ethanol-Induced Ulcers in Rats英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2007,ArticleID65873,6pages doi:10.1155/2007/65873 ResearchArticle AntioxidantMechanismisInvolvedinthe GastroprotectiveEffectsofOzonizedSun?ower OilinEthanol-InducedUlcersinRats ZullytB.ZamoraRodr′?guez,1RicardoGonza′lezAlvarez,′ 1Daile′nGuanche,1NelsonMerino,2 FrankHerna′ndezRosales,1SilviaMene′ndezCepero,1YaimaAlonsoGonza′lez,1andSiegfriedSchulz3 1 2 LaboratoryofBiologicalAssays,DepartmentofBiomedicalResearch,OzoneResearchCenter,P.O.Box6414,Havana,Cuba LaboratoryofPathologicalAnatomy,DepartmentofBiomedicalResearch,CenterofPharmaceuticalChemistry, P.O.Box16042,Havana,Cuba 3 VeterinaryServicesandLaboratoryAnimalMedicine,PhilippsUniversityofMarburg,35033Marburg,Germany Received31August2006;Revised4December2006;Accepted5December2006 Thisresearchwasperformedinordertodeterminethepotentialprotectivee?ectsofozonizedsun?oweroil(OSO)intheinjury ofratgastricmucosainducedbyabsoluteethanolandaswellastoelucidatetheroleofreactiveoxygenspecies(ROS),lipidper- oxidation,andsomeimportantconstituentsofantioxidantdefensesuchassuperoxidedismutase(SOD),glutathioneperoxidase (GSH-Px),andcatalase(CAT)inthesee?ects.OSOwasadministeredtoratsintragastricallybyacannulaanditwasapplieddur- ingfourdaystoanimals.ThedosesofOSOadministereddailytoeachgroupofratswere4,12,and24mg/kg,respectively,and onehourafterthelasttreatment,absoluteethanol(1mL/200mgbodyweight)wasadministered.Ourresultsshowedthatgastric ulcerindexwassigni?cantlyreducedinratspretreatedwithOSOascomparedwithethanol-treatedcontrols.However,inrats pretreatedwithOSO,nosigni?cantreductionofTBARScontentingastricmucosawasfoundascomparedtothoseratstreated withethanolalone.Incontrast,SODandGSH-Pxactivitiesweresigni?cantlyincreasedingastricmucosaofOSO-pretreatedrats withrespecttothosetreatedwithethanolalone.Insummary,ourresultsdemonstratethatOSOpretreatmentexertsprotective e?ectsinethanol-inducedgastriculcersinrats.Furthermore,theseresultsprovideevidencethattheseprotectivee?ec