Approaching intermolecular interactions and membrane activity of taxol by FTIR Spectroscopy-implications for anticancer therapeutics英文文献资料.docVIP

Vol.2, No.8, 832-835 (2010) HEALTH doi:10.4236/health.2010.28125 Approaching intermolecular interactions and membrane activity of taxol by FTIR Spectroscopy-implications for anticancer therapeutics Erhan Süleymanoglu Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Gazi University, Ankara, Turkey; esuleymanoglu@.tr Received 16 October 2009; revised 30 November 2009; accepted 2 December 2009. ABSTRACT a high dissolution rate therefore becomes a necessity in order to achieve their therapeutic dose. Phospholipids can be used to solubilise such drugs, with spontaneous formation of complexes. Thus, encapsulation of hydro- philic and binding of amphipathic as well as lipophilic drugs is possible. Studying such drug-lipid recognitions is important also in terms of aquiring detailed knowledge of cellular functions of biomembranes and developing novel models for better understanding of drug action [3]. Pharmaceutical and physicochemical analyses of drug- membrane complexes have been studied by various analytical methods employing a variety of drugs and model membranes. Thermodynamic, spectroscopic and microscopy approaches were used for structural chara- cteization of these macromolecular associations. Among these, vibrational spectroscopy (Infrared and Raman spe- ctroscopy) provide useful information on dynamic changes occuring after complex formation of various biomolecules [4], making it a preferred method of analysis which deserves to be employed also in drug- membane studies. In its most popular mode of appli- cation, the infrared (IR) measurements involve water removal from samples, which often give rise to erra- neous interpretations of the resulting spectra. Undou- btedly, understanding the interactions of drugs with biomembrane or with liposomal lipids following vesicle encapsulation would help to develop improved therapeuti