Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men英文文献资料.docVIP

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Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men英文文献资料.doc

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Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men英文文献资料

HindawiPublishingCorporation AIDSResearchandTreatment Volume2012,ArticleID103072,5pages doi:10.1155/2012/103072 ResearchArticle AssessingtheAssociationbetweenLeptinand BoneMineralDensityinHIV-InfectedMen MadhuN.Rao,1,2MorrisSchambelan,1,2VivaW.Tai, 2DonaldI.Abrams, 1,3 HootanKhatami, PeterJ.Havel, GiorgosSakkas, 4 5 6 andKathleenMulligan 1,2 1 2 DepartmentofMedicine,UniversityofCalifornia,SanFrancisco,CA94143,USA DivisionofEndocrinology,SanFranciscoGeneralHospital,1001PotreroAvenue,Building30Room3501K, SanFrancisco,CA94110,USA 3 4 5 DivisionofHematologyandOncology,SanFranciscoGeneralHospital,995PotreroAvenue,SanFrancisco,CA94110,USA DaiichiSankyoPharmaDevelopment,399ThornallStreetN.45,Edison,NJ08837,USA DepartmentofMolecularBiosciences,SchoolofVeterinaryMedicineandDepartmentofNutrition,UniversityofCalifornia, Davis,1093HaringHall,Davis,CA95616,USA 6 DepartmentofMedicine,UniversityGeneralHospitalofLarissa,UniversityofThessaly,Mezourlo,TK411-10Larissa,Greece CorrespondenceshouldbeaddressedtoMadhuN.Rao,madhu.rao@ Received3February2012;Accepted3July2012 AcademicEditor:GlendaGray Copyright?2012MadhuN.Raoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. HIV-infectedindividualsareatriskfordecreasedbonemineraldensity(BMD).Theknownriskfactorsforbonelossdonotfully explaintheincreasedriskinthispopulation.Thereisemergingevidencethatleptin,ahormonesecretedbyadipocytes,plays animportantroleinbonemetabolism.Severalstudieshaveassessedtherelationshipbetweenleptinandbonedensityinhealthy adults,buttherearefewsuchstudiesinHIV-infectedindividuals.Furthermore,HIVinfectedindividualsonantiretroviraltherapy areatincreasedriskforalteredfatdistribution,whichmayimpacttherelationshipbetweenleptinandBMD.Inacross-sectional analysisofdatain107HIV-infectedmen,wedeterminedwhetherserumleptinlevelswereassociatedwithwhole-bodyBMDan