Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers英文文献资料.docVIP

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Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers英文文献资料.doc

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Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers英文文献资料

HindawiPublishingCorporation InternationalJournalofVascularMedicine Volume2012,ArticleID968761,7pages doi:10.1155/2012/968761 ClinicalStudy BenfotiamineCounteractsSmoking-InducedVascular DysfunctioninHealthySmokers AlinStirban,1,2SimonaNandrean, 1 StanleyKirana, ChristianG¨otting, 1 1 3 IoanAndreiVeresiu, 4 andDiethelmTschoepe 1 DiabetesCenter,HeartandDiabetesCenterNRWBadOeynhausen,RuhrUniversityofBochum, Georgstrasse11,32545BadOeynhausen,Germany 2 3 Pro?lInstituteforMetabolicResearch,Hellersbergstrasse9,41460Neuss,Germany InstituteforLaboratoryandTransfusionMedicine,HeartandDiabetesCenterNRW,BadOeynhausen, RuhrUniversityofBochum,Georgstrasse11,32545BadOeynhausen,Germany CenterforDiabetes,NutritionandMetabolicDiseases,“IuliuHatieganu”University,Str.Clinicilornr.2, 400006Cluj-Napoca,Romania 4 CorrespondenceshouldbeaddressedtoAlinStirban,alin.stirban@pro? Received13February2012;Revised22August2012;Accepted5September2012 AcademicEditor:TomokiHashimoto Copyright?2012AlinStirbanetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Background. Smoking induces endothelial dysfunction (ED) mainly by exacerbating oxidative stress (OS) and in?ammation. Benfotiamine,athiamineprodrugwithhighbioavailability,preventsnicotine-inducedvasculardysfunctioninrats.Itremained unknown whether this e?ect also occurs in humans. Methods. Therefore, 20 healthy volunteers (mean age: 38 years) were investigatedtwice,7–10daysapartinarandomized,cross-over,andinvestigator-blindeddesign.Vascularfunctionwasassessed by ?ow-mediated vasodilatation (FMD) of the brachial artery and by measurements of the soluble vascular cell adhesion molecule(sVCAM)-1.Investigationswereperformedafteranovernightfastaswellas20minutesafteronecigarettesmoking. Onanotherday,thesameprocedurewasappliedfollowinga3-dayoraltherapywithbenfotiamine(1050mg/day).Tenpatients we