Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer英文文献资料.docVIP

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Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer英文文献资料.doc

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Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2009,ArticleID625394,8pages doi:10.1155/2009/625394 ResearchArticle Bene?tofWholePelvicRadiotherapy CombinedwithNeoadjuvantAndrogenDeprivationfor theHigh-RiskProstateCancer PiotrMilecki, 1 MaciejBaczyk, JanuszSkowronek, AndrzejAntczak, 2 3 4 andPiotrMartenka 1 ZbigniewKwias, 4 1 2 3 4 DepartmentofRadiotherapy,GreaterPolandCancerCentre,Pozna′n61-866,Poland DepartmentofNuclearMedicine,MedicalUniversity,Pozna′n60-355,Poland DepartmentofBrachytherapy,GreaterPolandCancerCentre,Pozna′n61-866,Poland FacultyofUrology,MedicalUniversity,Pozna′n61-285,Poland CorrespondenceshouldbeaddressedtoPiotrMilecki,ecki@wco.pl Received22March2009;Accepted27July2009 RecommendedbyDaeheeKang Aim.Tostudywhetheruseofneoadjuvantandrogendeprivationtherapy(N-ADT)combinedwithwholepelvicradiotherapy (WPRT) for high-risk prostate cancer patients was associated with survival bene?t over prostate radiotherapy (PORT) only. MaterialandMethods.Between1999and2004,162high-riskprostatecancerpatientsweretreatedwithradiotherapycombined withlong-termandrogendeprivationtherapy(L-ADT).Patientswereprospectivelyassignedintotwogroups:A(N-ADT+WPRT +L-ADT)n=70pts,B(PORT+L-ADT)n=92pts.Results.The5-yearactuarialoverallsurvival(OS)rateswere89%forAand 78%forB(P=.13).The5-yearactuarialcausespeci?csurvival(CSS)rateswereA=90%andB=79%(P=.01).Biochemical progression-freesurvival(bPFS)rateswere52%versus40%(P=.07),forgroupsAandB,respectively.Conclusions.TheWPRT combinedwithN-ADTcomparedtoPORTforhigh-riskpatientsresultedinimprovementinCSSandbPFS;howevernoOS bene?twasobserved. Copyright?2009PiotrMileckietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. 1.Introduction versus prostate only), and ways of the most e?cient com- bination with androgen deprivation therapy (neoadjuvant vers