Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome Patients英文文献资料.docVIP

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Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome Patients英文文献资料.doc

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Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome Patients英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID363845,9pages doi:10.1155/2012/363845 ResearchArticle BerberineImprovesInsulinSensitivityby InhibitingFatStoreandAdjustingAdipokinesPro?lein HumanPreadipocytesandMetabolicSyndromePatients JingYang, LuXu, andMingLi 1JinhuaYin,1,2HongfeiGao,1LinxinXu,1,2YanWang,1 2 2 1 2 FirstA?liatedHospital,ShanxiUniversityofMedical,Taiyuan030001,China EndocrineKeyLaboratoryoftheMinistryofHealth,DepartmentofEndocrinology,PekingUnionMedicalCollegeHospital, ChineseAcademyofMedicalSciences,1Shuaifuyuan,Wangfujing,Beijing100730,China CorrespondenceshouldbeaddressedtoMingLi,lmpeking@ Received9October2011;Revised29December2011;Accepted29December2011 AcademicEditor:HaoXu Copyright?2012JingYangetal.Thisisanopenaccess articledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Berberineisknowntoinhibitthedi?erentiationof3T3-L1cellsinvitro,improveglycemiccontrol,andattenuatedyslipidemiain clinicalstudy.Theaimofthisstudywastoinvestigatethee?ectsofberberineonpreadipocytesisolatedfromhumanomentalfat andinmetabolicsyndromepatientstreatedwithberberinefor3months.Wehaveshownthattreatmentwith10μMberberine resulted in a major inhibition of human preadipocyte di?erentiation and leptin and adiponectin secretion accompanied by downregulationofPPARγ2,C/EBPα,adiponectin,andleptinmRNAexpression.After3monthsoftreatment,metabolicsyndrome patientsshoweddecreaseintheirBMI(31.5± 3.6versus27.4± 2.4kg/m )andleptinlevels(8.01versus5.12μg/L),aswellas 2 leptin/adiponectinratioandHOMA-IR.Theseresultssuggestthatberberineimprovesinsulinsensitivitybyinhibitingfatstore andadjustingadipokinepro?leinhumanpreadipocytesandmetabolicsyndromepatients. 1.Introduction Berberineisanisoquinolinederivativealkaloidisolated from many kinds of medicinal herbs,