Biphasic Effect of Curcumin on Morphine Tolerance A Preliminary Evidence from CytokineChemokine Protein Array Analysis英文文献资料.docVIP

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Biphasic Effect of Curcumin on Morphine Tolerance A Preliminary Evidence from CytokineChemokine Protein Array Analysis英文文献资料.doc

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Biphasic Effect of Curcumin on Morphine Tolerance A Preliminary Evidence from CytokineChemokine Protein Array Analysis英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2011,ArticleID452153,11pages doi:10.1093/ecam/neq018 OriginalArticle BiphasicEffectofCurcuminonMorphineTolerance: APreliminaryEvidencefromCytokine/ChemokineProtein ArrayAnalysis Jui-An Lin,1,2,3,4 Jenn-Han Chen,1,5 Yuan-Wen Lee, 2 Chao-Shun Lin, Ming-Hui Hsieh, 7 2 2 Chuen-ChauChang, 2 Chih-ShungWong, 6 JudyJu-YiChen, Geng-ChangYeh, 1,8 Feng-YenLin,1,2,3,4andTa-LiangChen1,2,3,4 1 2 3 4 GraduateInstituteofClinicalMedicine,CollegeofMedicine,TaipeiMedicalUniversity,Taiwan DepartmentofAnesthesiology,TaipeiMedicalUniversityHospital,TaipeiMedicalUniversity,Taiwan DepartmentofAnesthesiology,SchoolofMedicine,CollegeofMedicine,TaipeiMedicalUniversity,Taiwan DepartmentofAnesthesiology,AnestheticsandToxicologyResearchCenter,TaipeiMedicalUniversityHospital, TaipeiMedicalUniversity,Taiwan 5 6 7 8 CancerCenter,Wan-FangHospital,TaipeiMedicalUniversity,Taiwan DepartmentofAnesthesiology,CathayGeneralHospital,Taipei,Taiwan PritzkerSchoolofMedicine,UniversityofChicago,IL,USA DepartmentofPediatrics,TaipeiMedicalUniversityHospital,Taipei,Taiwan CorrespondenceshouldbeaddressedtoFeng-YenLin,g870905@.twandTa-LiangChen,ndmcm93@.tw Received22June2009;Accepted8February2010 Copyright?2011Jui-AnLinetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Theaimofthisstudywastoevaluatethee?ectofcurcuminonmorphinetoleranceandthecorrespondingcytokine/chemokine changes.MaleICRmiceweremadetoleranttomorphinebydailysubcutaneousinjectionfor7days.Intraperitonealinjections ofvehicle, low-doseorhigh-dosecurcumin were administered 15minafter morphineinjection, either acutely orchronically for7 daysto test thee?ect ofcurcumin onmorphine-induced antinociception anddevelopmentofmorphinetolerance. On day 8, cumulative dose-response curves were generated and the 50% of maxi