Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae英文文献资料.docVIP

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Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae英文文献资料.doc

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Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae英文文献资料

HindawiPublishingCorporation InternationalJournalofMicrobiology Volume2010,ArticleID930465,10pages doi:10.1155/2010/930465 ResearchArticle BoricAcidDisturbsCellWallSynthesisin Saccharomycescerevisiae MartinSchmidt,JaronZ.Schaumberg,CourtneyM.Steen,andMichaelP.Boyer BiochemistryandNutrition,DesMoinesUniversity,3200GrandAvenue,DesMoines,IA50312,USA CorrespondenceshouldbeaddressedtoMartinSchmidt,mschmidt@ Received6August2010;Revised20October2010;Accepted16November2010 AcademicEditor:RobertP.Gunsalus Copyright?2010MartinSchmidtetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Boricacid(BA)hasbroadantimicrobialactivity thatmakesitapopulartreatmentforyeastvaginitisincomplementaryand alternativemedicine.InthemodelyeastS.cerevisiae,BAdisturbsthecytoskeletonatthebudneckandimpairstheassemblyofthe septationapparatus.BAtreatmentcausescellstoformirregularseptaandleadstothesynthesisofirregularcellwallprotuberances thatextendfarintothecytoplasm.Thethick,chitin-richseptathatareformedduringBAexposurepreventseparationofcellsafter abscissionandcausetheformationofcellchainsandclumps.AsaresponsetotheBAinsult,cellssignalcellwallstressthrough theSlt2ppathwayandincreasechitinsynthesis,presumablytorepaircellwalldamage. 1.Introduction ring (CAR) by the addition of myosin and actin, among otherproteins[8,9].Tocompleteabscission,thelastphase ofcytokinesis,thecells?rstseparatemotheranddaughter cells with a chitin primary septum. The deposition of glucan and mannoprotein-rich cell wall material on the mother and daughter side of the primary septum later completesthetrilaminarseptumthatcanbeobservedunder normalcultureconditions.Adisturbanceintheassemblyof the septation apparatus—the cohesive functional unit that constructstheprimary septum—leadstotheformationof highlyaberrantsepta[10,11].Theseptaformedunderthese conditions do not allow f