c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes英文文献资料.docVIP

下载本文档

2
0
约2.24万字
约 7页
2017-05-10 发布于上海
举报
版权申诉

c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes英文文献资料.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes英文文献资料

HindawiPublishingCorporation JournalofTransplantation Volume2012,ArticleID348604,6pages doi:10.1155/2012/348604 ResearchArticle c-Jun-N-TerminalKinaseSignalingIsInvolvedin Cyclosporine-InducedEpithelialPhenotypicChanges NicolasPallet, 1EricThervet,1,2andDanyAnglicheau 1,3 1 2 3 Unit′eINSERMU775,CentreUniversitairedesSaints-P`eres,Universit′eParisDescartes,75006Paris,France ServicedeN′ephrologie,H?opitalEurop′eenGeorgesPompidou,75015Paris,France ServicedeTransplantationR′enale,H?opitalNecker,Universit′eParisDescartes,75006Paris,France CorrespondenceshouldbeaddressedtoNicolasPallet,npallet@yahoo.fr Received24May2011;Accepted15August2011 AcademicEditor:BruceKaplan Copyright?2012NicolasPalletetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Tubularepithelialcellsplayacentralroleinthepathogenesisofchronicnephropathies.Previoustoxicogenomicstudieshave demonstratedthatcyclosporine-(CsA-)inducedepithelialphenotypicchanges(EPCs)arereminiscentofanincompleteepithelial tomesenchymaltransition(EMT)inaTGF-β-independentmanner.Furthermore,weidenti?edendoplasmicreticulum(ER)stress asapotentialmechanismthatmayparticipateinthemodulationoftubularcellplasticityduringCsAexposure.Becausec-jun-N- terminalkinase(JNK),whichisactivatedduringERstress,isimplicatedinkidney?brogenesis,weundertookthecurrentstudy toidentifytheroleofJNKsignalinginEPCsinducedbyCsA.Inprimaryculturesofhumanrenalepithelialcells,CsAactivates JNKsignaling,andthetreatmentwithaJNKinhibitorreducestheoccurrenceofcellshapechanges,E-cadherindownregulation, cellmigration,andSnail-1expression.OurresultssuggestthatCsAactivatesJNKsignaling,which,inturn,mayparticipateinthe morphologicalalterationsthroughtheregulationofSnail-1expression. 1.Introduction dependentepithelialphenotypicchanges(EPCs).However, we have not observed de novo α-smooth muscle actin (α- SMA)expression,suggestingthatCsAind