Calcific Uremic Arteriolopathy Pathophysiology, Reactive Oxygen Species and Therapeutic Approaches英文文献资料.docVIP

REVIEW REVIEW Oxidative Medicine and Cellular Longevity 3:2, 109-121; March/April 2010; ? 2010 Landes Bioscience Calci?c uremic arteriolopathy Pathophysiology, reactive oxygen species and therapeutic approaches Kurt M. Sowers and Melvin R. Hayden * 1,2 3-5, University of Maryland; Division of Nephrology; Physiology; University of Missouri School of Medicine; Departments of Internal Medicine; Endocrinology Diabetes and 1 2 3 4 Diabetes and Cardiovascular Disease Research Center; University of Missouri School of Medicine; Columbia, MI USA Metabolism; 5 Key words: calcific obliterative arteriolopathy, calciphylaxis, fetuin-A, inflammation, oxidative stress, sodium thiosulfate, ultrastructure, vascular calcification Abbreviations: CUA, calcific uremic arteriolopathy; CKD, chronic kidney disease; ESRD, end stage renal disease; VSMC, vascular smooth muscle cell(s); ROS, reactive oxygen species; MGP, matrix GLA protein; AHSG, alpha2-heremans-schmid glycoprotein; NFκB, nuclear factor kappaB; RANKL, receptor activator of NFκB ligand; TNFα, tumor necrosis factor alpha; IL-1, interleukin-1; IL-6, interleukin-6; ET-1, endothelin-1; eNOS, endothelial nitric oxide synthase; NO, nitric oxide; LDL-C, low density lipoprotein-cholesterol; HDL-C, high density lipoprotein-cholesterol; NADPH, nicotinamide adenine dinucleotide phosphate reduced; ADMA, asymmetrical dimethyl arginine; TNFα, tumor necrosis factor alpha; hsCRP, highly sensitive C reactive protein; NKF KDOQI, national kidney foundation kidney disease outco