Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes英文文献资料.docVIP

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Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes英文文献资料.doc

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Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes英文文献资料

HindawiPublishingCorporation ExperimentalDiabetesResearch Volume2011,ArticleID957901,7pages doi:10.1155/2011/957901 ResearchArticle CardiacAutonomicFunctionCorrelateswithArterialStiffnessin theEarlyStageofType1Diabetes S.Liatis,K.Alexiadou,A.Tsiakou,K.Makrilakis,N.Katsilambros,andN.Tentolouris FirstDepartmentofInternalMedicine,DiabetesCenter,AthensUniversityMedicalSchoolandGeneralHospitalofAthens“Laiko”, 11527Athens,Greece CorrespondenceshouldbeaddressedtoS.Liatis,sliatis@med.uoa.gr Received29April2011;Accepted19June2011 AcademicEditor:AlexanderKokkinos Copyright?2011S.Liatisetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Arterialsti?nessisincreasedintype1diabetes(T1D),beforeanyclinicalcomplicationsofthediseaseareevident.Theaimofthe presentpaperwastoinvestigatetheassociationbetweencardiacautonomicfunctionandarterialsti?nessinacohortofyoung T1D patients, without history of hypertension and any evidence of macrovascular and/or renal disease. Large artery sti?ness wasassessedbymeasurementofcarotid-femoralpulsewavevelocity(PWV).Cardiacautonomicfunctionwasassessedbythe cardiovasculartestsproposedbyEwingandClarke.Patientswithahighcardiacautonomicneuropathyscore(≥4)hadsigni?cantly higherPWVthanthosewith alowscore(0-1).Anegative,heart rate-independent,correlationbetweenPWVandheart rate variationduringrespirationwasobserved(r=?0.533,P0.001).Inmultivariableanalysis,E/Iindexwasthestrongestcorrelate ofPWV(β-coe?cient=?0.326, P =0.002).Cardiacparasympatheticfunctionisastrongpredictoroflargearterialsti?ness,in youngT1Dpatientsfreeofmacrovascularandrenalcomplications. 1.Introduction may occur within two years of the diagnosis in patients withT1D[16].Reducedcardiovascularautonomicfunction has been associated with increased total mortality and cardiovascularmorbidityaswellasmortality[17,18]. Few previous studies have explored the