Cardiac Imaging Using Clinical 1.5？T MRI Scanners in a Murine IschemiaReperfusion Model英文文献资料.docVIP

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Cardiac Imaging Using Clinical 1.5？T MRI Scanners in a Murine IschemiaReperfusion Model英文文献资料.doc

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Cardiac Imaging Using Clinical 1.5？T MRI Scanners in a Murine IschemiaReperfusion Model英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2011,ArticleID185683,8pages doi:10.1155/2011/185683 ResearchArticle CardiacImagingUsingClinical1.5TMRIScannersin aMurineIschemia/ReperfusionModel JakobG.J.Voelkl, GertKlug, AlexanderLoizides, andBernhardMetzler 1 BernhardJ.Haubner, 2 1 ChristianKremser, 1 2 AgnesMayr, 1 2 1 SilvanaM¨uller, OtmarPachinger, MichaelSchocke, 2 1 1 2 DepartmentofInternalMedicineIII(Cardiology),InnsbruckMedicalUniversity,Anichstr.35,6020Innsbruck,Austria DepartmentofRadiologyI,InnsbruckMedicalUniversity,Anichstr.35,6020Innsbruck,Austria CorrespondenceshouldbeaddressedtoBernhardMetzler,bernhard.metzler@uki.at Received13July2010;Accepted26October2010 AcademicEditor:AndreaVecchione Copyright?2011JakobG.J.Voelkletal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Toperformcardiacimaginginmicewithouthavingtoinvestinexpensivededicatedequipment,weadaptedaclinical1.5Tesla(T) magneticresonanceimaging(MRI)scannerforuseinamurineischemia/reperfusionmodel.Phase-sensitiveinversionrecovery (PSIR)sequencefacilitatedthedeterminationofinfarctsizesinvivobylategadoliniumenhancement.Resultswerecomparedto histologicalinfarctareasinmiceafterischemia/reperfusionprocedurewithagoodcorrelation(r =0.807,P.001).Inaddition, fractionalareachange(FAC)wasassessedwithsingleslicecineMRIandwasmatchedtoinfarctsize(r =?0.837)andfractional shortening(FS)measuredwithechocardiography(r =0.860);bothP .001.Here,wedemonstratetheuseofclinical1.5MRI scannersasafeasiblemethodforbasicphenotypinginmice.Thesewidelyavailablescannersarecapableofinvestigatinginvivo infarctdimensionsaswellasassessmentofcardiacfunctionalparametersinmicewithreasonablethroughput. 1.Background research[5–9].However,thesedevicesspecializedforsmall animal imaging, are expensive and not accessible to most researchers. Although