Cardiovascular Risk in Patients with Psoriatic Arthritis英文文献资料.docVIP

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Cardiovascular Risk in Patients with Psoriatic Arthritis英文文献资料.doc

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Cardiovascular Risk in Patients with Psoriatic Arthritis英文文献资料

HindawiPublishingCorporation InternationalJournalofRheumatology Volume2012,ArticleID714321,11pages doi:10.1155/2012/714321 ReviewArticle CardiovascularRiskinPatientswithPsoriaticArthritis TracyY.Zhu,EdmundK.Li,andLai-ShanTam DepartmentofMedicineandTherapeutics,PrinceofWalesHospital,TheChineseUniversityofHongKong,Shatin,N.T.,HongKong CorrespondenceshouldbeaddressedtoLai-ShanTam,lstam@.hk Received10January2012;Revised14February2012;Accepted21February2012 AcademicEditor:GeorgeD.Kitas Copyright?2012TracyY.Zhuetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Psoriaticarthritis(PsA)isanin?ammatoryarthritisassociatedwithpsoriasis.Inadditiontoskinandjointinvolvement,thereis increasingevidencesuggestingthatpatientswithPsAalsohaveanincreaseinriskofclinicalandsubclinicalcardiovasculardiseases, mostlyduetoacceleratingatherosclerosis.Bothconventionalandnonconventionalcardiovascularriskfactorscontributetothe increasedcardiovascularriskinPsA.Chronicin?ammationplaysapivotalroleinthepathogenesisofatherosclerosisinPsA,acting independentlyand/orsynergisticallywiththeconventionalriskfactors.Inthispaper,wediscussthecurrentliteratureindicating thatpatientswithPsAareatriskofcardiovasculardiseases. 1.Introduction atherosclerosis”, “endothelial function”, “lipids”, “hyperten- sion”, “diabetes mellitus”, “homocysteine”, or “acute-phase proteins”inthetitle,abstract,orkeywordswithlimitssetto includehumansandstudieswritteninEnglish.Articleswere deemedeligibleiftheyincluded(cardiovascular)mortality andmorbidity,and/orsubclinicalcardiovascularmorbidity, and/or data about cardiovascular risk factors, and/or the e?ectsoftreatmentoncardiovascularriskinPsA.Theinitial search yielded 528 abstracts, which were narrowed to 90 potentially relevant articles by preliminary review of the titlesandbyexcludingreviewarticlesandcasereport(n = 126).Twentyarticleswer