Case of Advanced Recurrent Glioblastoma Successfully Treated with Monoterpene Perillyl Alcohol by Intranasal Administration英文文献资料.docVIP

Journal of Cancer Therapy, 2011, 2, 16-21 doi:10.4236/jct.2011.21003 Published Online March 2011 (http://www.SciRP.org/journal/jct) Case of Advanced Recurrent Glioblastoma Successfully Treated with Monoterpene Perillyl Alcohol by Intranasal Administration –—Intranasal POH Promotes Long-Term Survival of Recurrent Glioma Clovis O. Da Fonseca , Raphael M. Teixeira , Ricardo Ramina , Giovana Kovaleski , 1 2 3 4 5 2 Júlio Thome Silva 1 , Janaína Nagel , Thereza Quirico-Santos 1 Department of General and Specialized Surgery; Unit of Clinical Research, Fluminense Federal University, RJ, Brazil; Institute of 2 Biology, Fluminense Federal University; Institute of Neurology of Curitiba, Paraná; Medical Oncology Service, Rio de Janeiro; Getulio Vargas Estate Hospital, Rio de Janeiro. Email: clovis.orlando@.br, tquirico@vm.uff.br 3 4 5 Received November 1 , 2010; revised November 15 , 2010; accepted November 17 , 2010. st th th ABSTRACT We report a case of recurrent glioblastoma (GBM) successfully treated with the Ras inhibitor monoterpene perillyl al- cohol by intranasal administration. A 37-years-old white woman had been previously submitted to three neurosurgical procedures, in June 2000 for radical tumor excision of grade II astrocytoma; in July 2003 for first recurrence of type IV glioma and in August 2004 for GBM recurrence. After last surgery, patient started a new cycle of chemotherapy but was refractory to treatment, presented clinical adverse effects and resonance image scan showed no reduction of tu- moral lesion. Patient was then considered out of therapeutic possib