Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions英文文献资料.docVIP

J. Biomedical Science and Engineering, 2011, 4, 200-206 JBiSE doi:10.4236/jbise.2011.43028 Published Online March 2011 (http://www.SciRP.org/journal/jbise/). Cationic polypeptides in a concept of oppositely charged po- lypeptides as prevention of postsurgical intraabdominal adhe- sions Karolin Isaksson, Daniel ?kerberg, Katarzyna Said, Bobby Tingstedt Department of Surgery, University Hospital of Lund, Sweden. Email: bobby.tingstedt@med.lu.se Received 29 November 2010; revised 3 January 2011; accepted 5 January 2011. ABSTRACT 1. INTRODUCTION Postoperative abdominal adhesion formation is a sig- nificant clinical problem worldwide, especially follow- ing lower abdominal surgery [1,2]. Adhesions contain fibrotic tissue that can create bridges between bowels, organs and the abdominal wall, thus creating intraab- dominal problems. Abdominal adhesions are not only the leading cause of small bowel obstruction, a common diagnosis often demanding surgical treatment, but also cause abdominal pain and female infertility [3]. The pathogenesis is not completely elucidated but the overall picture is quite clear [4]. The peritoneal surface is very delicate and susceptible to damage. In the process of adhesion formation, the plasmin system plays a cru- cial part with an imbalance between fibrin formation and degradation at the injured peritoneal site [5-6]. Important factors involved in degradation and formation of local peritoneal adhesions are tPA and PAI-1 [7-10]. Background: Two differently charged polypeptides, α-poly-L-lysine and poly-L-glutamate, have previ- ously been shown to effectively reduce postoperative intraabdominal adhesions. Though α-poly-L-lysine showed toxicity in doses too close to the lowest the- rapeutic dose, the aim in the present study was to investigate the possible antiadhesive effect of another four cationic polypeptides. Materials/Methods: 1