Caffeoylquinic Acids Are Major Constituents with Potent Anti-Influenza Effects in Brazilian Green Propolis Water Extract英文文献资料.docVIP

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Caffeoylquinic Acids Are Major Constituents with Potent Anti-Influenza Effects in Brazilian Green Propolis Water Extract英文文献资料.doc

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Caffeoylquinic Acids Are Major Constituents with Potent Anti-Influenza Effects in Brazilian Green Propolis Water Extract英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2011,ArticleID254914,7pages doi:10.1155/2011/254914 ResearchArticle CaffeoylquinicAcidsAreMajorConstituentswithPotent Anti-In?uenzaEffectsinBrazilianGreenPropolisWaterExtract TomohikoUrushisaki, JunjiHosokawa-Muto, 1 TomoakiTakemura, ShigemiTazawa, 1 1MayukoFukuoka, 2,3 YokoAraki, andKazuoKuwata2,3,4 4 1 1 2 NagaragawaResearchCenter,APICo.,Ltd.,692-3Nagara,Yamasaki,Gifu502-0071,Japan UnitedGraduateSchoolofDrugDiscoveryandMedicalInformationSciences,GifuUniversity, 1-1Yanagido,Gifu501-1193,Japan 3 4 CREST,JapanScienceandTechnologyAgency,4-1-8Honcho,Kawaguchi,Saitama332-0012,Japan CenterforEmergingInfectiousDiseases,GifuUniversity,1-1Yanagido,Gifu501-1194,Japan CorrespondenceshouldbeaddressedtoKazuoKuwata,kuwata@gifu-u.ac.jp Received18November2010;Revised27December2010;Accepted9January2011 Copyright?2011TomohikoUrushisakietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. In?uenzaA viral infections reached pandemic levels in 1918,1957, 1968, and, mostrecently, in 2009 with theemergence of theswine-originH1N1in?uenzavirus.Thedevelopmentofnoveltherapeuticsorprophylacticsforin?uenzavirusinfectionis urgentlyneeded.Weexaminedtheevaluationoftheanti-in?uenzavirus(A/WSN/33(H1N1))activityofBraziliangreenpropolis waterextract(PWE)anditsconstituentsbycellviabilityandreal-timePCRassays.Our?ndingsshowedstrongevidencethat PWEhasananti-in?uenzae?ectanddemonstratethatca?eoylquinicacidsaretheactiveanti-in?uenzacomponentsofPWE. Furthermore,wehavefoundthattheamountofviralRNApercellremainedunchangedeveninthepresenceofPWE,suggesting thatPWEhasnodirectimpactonthein?uenzavirusbutmayhaveacytoprotectiveactivitybya?ectinginternalcellularprocess. These?ndingsindicatethatca?eoylquinicacidsaretheactiveanti-in?uenzacomponentsofPWE.Above?ndingsmightfacilitate