Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment英文文献资料.docVIP

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Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment英文文献资料.doc

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Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment英文文献资料

HindawiPublishingCorporation ObstetricsandGynecologyInternational Volume2012,ArticleID248926,7pages doi:10.1155/2012/248926 ReviewArticle CausalACTH-DepotTherapyduringPregnanciesfollowing InfertilityTreatment RudolfKlimek,MarekKlimek,PeterGralek,andDariuszJasiczek FertilityCentreCracow,PlacSzczepa′nski3,31-011Cracow,Poland CorrespondenceshouldbeaddressedtoRudolfKlimek,mmklimek@.pl Received29August2011;Accepted13March2012 AcademicEditor:HowardD.Homesley Copyright?2012RudolfKlimeketal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. The aim of this paper was to con?rm the e?cacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism.Theactivityofhypothalamic-pituitary-adrenalaxisplaysakeyroleinpregnancy.Suchnaturallystimulatedendogenous corticosteroidhormonesarefreefromunwantedsidee?ectsoftheirsyntheticsanalogs.LowlevelofmaternalbloodACTHand insu?cientincreaseofinducedbyhypothalamichormonesoxytocinases(cystine-β-aminopeptidases)wereindicationtoACTH- depottherapy(0.5mg/week)inourconsecutiveprospectivestudies.Contrarytoantenataluseofsyntheticcorticosteroids,there arenotemporallimitsofthistherapy,which hastobemoreoften recommendedintoclinicalprevention offetalmorbidity, treatmentofprematuredelivery,and?nallyeliminationofthenewborn’smortalitycausedbytheneuroendocrinologicalgestoses. 1.Introduction described the principles of chemical assay of the enzyme oxytocinaseusingassubstrateL-cystine-di-β-naphthylamide [8]. The following years brought an increasing interest in assessment of aminopeptidase activity in obstetrics, but in 1966 Babuna and Yenen published a study on the modi- ?cationoftheoriginalchemicalassessmentofoxytocinase thatinfacthinderedinvestigationsofenzymemonitoringin pr