大蒜素治疗病毒性心肌炎疗效分析.docVIP

大蒜素治疗病毒性心肌炎疗效分析 　　【摘要】 目的 探讨大蒜素治疗病毒性心肌炎(VMC)的疗效及其机制。方法 选择符合诊断标准的96例VMC患者，随机分为三组。A组32例，予常规西药治疗，B组32例在A组基础上加用黄芪注射液治疗，C组在A组基础上加用大蒜素注射液治疗，三组疗程均为30 d，观察治疗前后患者心律失常率、STT改变率及心脏肌钙蛋白T(cTnT)、肌酸激酶同工酶（CKMB）和白细胞介素18（IL18）检测水平的变化情况。结果 三组患者治疗后其心律失常率、STT改变率、cTnT和CKMB均显著下降（P＜0.01），A、B、C三组各观察指标有逐级改善趋势，C组改善幅度最大（P＜0.01）。C组患者治疗7、15、30 d后其血清 IL18水平均显著下降（P＜0.01），A、B组患者治疗15、30 d后其血清IL18水平均显著下降（P＜0.05或0.01），A、B、C三组患者治疗15、30 d后其血清 IL18水平有逐级下降趋势（P＜0.01），C组下降幅度最大（P＜0.01）。结论 大蒜素对VMC患者有良好的治疗效果，可能与其抑制病毒复制，恢复被病毒破坏的细胞免疫系统功能,减轻患者的免疫反应对其心肌的损伤，从而改善患者临床症状和心功能有关。 　　【关键词】 病毒性心肌炎；大蒜素；细胞因子；白细胞介素18 　　文章编号：1003-1383(2010)02-0120-02 中图分类号：R 542.2+2 文献标识码：A 　　doi:10.3969/j.issn.1003-1383.2010.02.002 　　 　　Analysis on the effect of garlicin for treating viral myocarditis 　　PAN Xingshou,LAN Jingsheng,LI Tianzi,HUANG Zhaohe, LIU Yan, LIANGYue,LAI Tengfang 　　(Cardiovascular Prevention Institute of Youjiang Medical University for Nationality,Cardiovascular 　　Department of Affiliated Hospitalof Youjiang Medical University for Nationality，Baise Guangxi 533000) 　　【Abstract】 Objective To explore the curative effect of garlicin on the treatment of viral myocarditis (VMC)and its mechanism. 　　Methods 96 patients with VMC were randomly divided into three groups.group A of 32 patients were given western conventional medicine,group B of 32 patients were given astragalus injection besides the conventional therapy,while group C were given garlic injection.The course in three groups were 30 days.The incidence of the arrhythmia,stt segment changes and the level of cTnT,CKMB,IL18 in patients were observed before and after thetreatment.ResultsThe incidence of the arrhythmia,stt segment changes and the level of cTnT,CKMB,IL18 decreased significantly in all the patients After treatment（P＜0.01）.and the observation indexes improved at the same time,especially the group C（P＜0.01）.the level of serum IL18 decreased significantly in the 7th,15th and the 30th day after treatment in group C (P＜0.01),while the level decreased si