食管癌根治术后预防性放射治疗的临床价值.pdfVIP

608 2002 11 24 6 C in J Oncol, November 2002, Vol 24, No. 6 肖泽芬 杨宗贻 梁军 苗延浚 汪楣 殷蔚伯 谷铣之 张德超 张汝刚 汪良骏 495 , ( 275 ) ( 220 ) 3~ 4 5 50 Gy, 25 ; 5~ 6 50~ 60 Gy, 25~ 30 5 39.4% 5 ( P = 0.4474) , 5 13. 1% 35. 1% ( P= 0.002 7) 16. 2% 3. 1% 0. 5% , 25. 9% 13. 2% 5. 8% ( P 0.05) 1. 8% , 4. 1% ( P 0. 05) , ; ; ; , ; , Clinical value of prophylactic radiotherapy after curative resection of esophageal carcinoma XIAOZef en, YANG Zongyi , LIANG Jun, MIAO Yanjun, WANG Mei, YIN Weibo, GUXianzhi, ZHANG Dechao, ZHANG ugang, WANG Liangjun. Department of adiation Oncology, Cancer Institute (Hosp ital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China Abstract Obj ective To evaluate t e clinical value of prop ylactic radiot erapy for esop ageal carcinoma after curative operation. Methods 495 esop ageal squamous cell cancer patients w o ad undergone radical resection were randomized by t e envelope met od into a surgery alone group ( S, 275) and a surgery plus radiot erapy group ( S + R, 220) . Radiation treatment was started 34 weeks after operation. T e portals encompassed t e w ole mediastinum and bilateral supraclavicular areas. A midplane dose of 50 ~ 60 Gy in 20~ 30 fractions over 5~ 6 weeks was delivered. Results 1. Survival rate: t e overall 5year survival rate was 39.4% . T ose of S alone and S+ R groups were 37. 1% and 41. 3% ( P= 0.447 4) . T e 5year survival rate for Stage patients were 13. 1% in S alone group and 35. 1% in R+ S group ( P = 0. 002 7) , 2. Pattern of failure: T e incidence of local recurrence intrat oracic lymp node metastasis, anastomotic recurrence and extra t oracic lymp node metastasis in S+ R group ( 16. 2% , 0. 5% and 3. 1%) were lower t an t ose (25. 9% , 5. 8% and 13. 2%)