Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment 英文参考文献.docVIP

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Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment 英文参考文献.doc

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Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment 英文参考文献

AnalysisofInsulinDosesofChineseType2Diabetic PatientswithIntensiveInsulinTreatment XiaolingCai,XueyaoHan,YingyingLuo,LinongJi* EndocrinologyandMetabolismDepartment,PekingUniversityPeople’sHospital,Beijing,China Abstract Background: To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabeticpatientswhoreceivedbasalbolusinsulintherapy. Methodology/PrincipalFindings:Totally2480patientsprescribedwithpre-mealbolusinsulinandbedtimebasalinsulin were included. The mean daily insulin doses was 38.22614.92IU/day, the mean daily insulin doses per weight was 0.5860.22IU/kg,themeanbolusinsulindosewas0.4460.17IU/kgandthemeanbasalinsulindosewas0.1360.08IU/kg. Themeanbasal/totaldailyinsulinratio(BD/TDD)was0.2360.08.Inmostpatients(47.94%),theBD/TDDwasbetween0.20 and0.30.Diabeticduration,BMI,HbA1c,fastingandpostprandialbloodglucoselevelwerepositivelyassociatedwithdaily insulin dose, while age was negatively associated with daily insulin dose. Diabetic duration, BMI, HbA1c, fasting blood glucose level, and using metformin were positively associated with BD/TDD ratio, while age, postprandial C peptide, postprandialbloodglucoselevelandCRElevelwerenegativelyassociatedwithBD/TDDratio. Conclusions/Significance:ThedailyinsulindosesofintensivetreatmentinChinesetype2diabeticpatientswas38.22IU/ day,themeandailyinsulindosesperweightwas0.58IU/kg,meanBD/TDDratiowas0.23. Citation:CaiX,HanX,LuoY,JiL(2012)AnalysisofInsulinDosesofChineseType2DiabeticPatientswithIntensiveInsulinTreatment.PLoSONE7(6):e38962. doi:10.1371/journal.pone.0038962 Editor:JianpingYe,PenningtonBiomedicalResearchCenter,UnitedStatesofAmerica ReceivedMarch26,2012;AcceptedMay16,2012;PublishedJune18,2012 Copyright:?2012Caietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Nofundingreceived. CompetingInterest