Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia 英文参考文献.docVIP

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Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia 英文参考文献.doc

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Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia 英文参考文献

DifferentialSialylationofSerpinA1intheEarly DiagnosisofParkinson’sDiseaseDementia SarahJesse1.,StefanLehnert1.,OlafJahn2,3,LucillaParnetti4,HilkkaSoininen5,Sanna-KaisaHerukka5, PetraSteinacker1,SaskiaTawfik1,HayrettinTumani1,ChristineA.F.vonArnim1,ManuelaNeumann6, HansA.Kretzschmar7,HasanKulaksiz8,MartinLenter9,JensWiltfang10,BorisFerger9, BastianHengerer9,MarkusOtto1* 1DepartmentofNeurology,UniversityofUlm,Ulm,Germany,2ProteomicsGroup,Max-Planck-InstituteforExperimentalMedicine,Goettingen,Germany,3DFGResearch Center for Molecular Physiology of the Brain, Goettingen, Germany, 4Department of Neurology, University of Perugia, Perugia, Italy, 5Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, 6Institute of Neuropathology, University of Zurich, Zurich, Switzerland, 7Institute of Neuropathology, Ludwig Maximilians University, Munich, Germany, 8Department of Internal Medicine, University of Ulm, Ulm, Germany, 9CNS Diseases Research, BoehringerIngelheimGmbHCo.KG,BiberachanderRiss,Germany,10DepartmentofPsychiatry,UniversityofEssen-Duisburg,Essen-Duisburg,Germany Abstract TheprevalenceofParkinson’sdisease(PD)increaseswithage.Upto50%ofPDshowcognitivedeclineintermsofamild cognitiveimpairmentalreadyinearlystagesthatpredictthedevelopmentofdementia,whichcanoccurinupto80%ofPD patientsoverthelongterm,calledParkinson’sdiseasedementia(PDD).Sofar,diagnosisofPD/PDDismadeaccordingto clinicalandneuropsychologicalexaminationswhilelaboratorydataisonlyusedforexclusionofotherdiseases.Theaimof thisstudywastheidentificationofpossiblebiomarkersincerebrospinalfluid(CSF)ofPD,PDDandcontrols(CON)which predict the development of dementia in PD. For this, a proteomic approach optimized for CSF was performed using 18 clinically well characterized patients in a first step with subsequent validation using 84 patients. Here, we detected differentially sialylated isoforms of Serpin A1 as marker for differentiation of PD versus PDD in CSF. Performing