Efficacy of Mycobacterium indicus pranii Immunotherapy as an Adjunct to Chemotherapy for Tuberculosis and Underlying Immune Responses in the Lung 英文参考文献.docVIP

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Efficacy of Mycobacterium indicus pranii Immunotherapy as an Adjunct to Chemotherapy for Tuberculosis and Underlying Immune Responses in the Lung 英文参考文献.doc

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Efficacy of Mycobacterium indicus pranii Immunotherapy as an Adjunct to Chemotherapy for Tuberculosis and Underlying Immune Responses in the Lung 英文参考文献

EfficacyofMycobacteriumindicuspraniiImmunotherapy asanAdjuncttoChemotherapyforTuberculosisand UnderlyingImmuneResponsesintheLung AnkanGupta1,FarhanJ.Ahmad2,FaizAhmad1,UmeshD.Gupta3,MohanNatarajan3, VishwamohanKatoch3¤,SangeetaBhaskar1* 1ProductDevelopmentCell,NationalInstituteofImmunology,NewDelhi,Delhi,India,2FacultyofPharmacy,JamiaHamdard,NewDelhi,Delhi,India,3Experimental AnimalFacilityandDepartmentofPathology,NationalJALMAInstituteforLeprosyandOtherMycobacterialDiseases,Agra,India Abstract Background:The9-month-longchemotherapyoftuberculosisoftenresultsinpoorcomplianceandemergenceofdrug- resistantstrains.So,improvedtherapeuticstrategyisurgentlyneeded.Immunotherapycouldbebeneficialfortheeffective managementofthedisease.PreviouslyweshowedtheprotectiveefficacyofMycobacteriumindicuspranii(MIP)whengiven asprophylacticvaccineinanimalmodelsoftuberculosis. Methods:WesoughttoinvestigatewhetherMIPcanbeusedasanadjuncttothechemotherapyinguineapigmodelsof tuberculosis.EfficacyofMIPwasevaluatedwhengivensubcutaneouslyorbyaerosol. Results: MIP-therapy as an adjunct to the chemotherapy was found to be effective in accelerating bacterial killing and improving organ pathology. MIP-immunotherapy resulted in higher numbers of activated antigen-presenting cells and lymphocytes in the infected lungs and also modulated the granulomatous response. Early increase in protective Th1 immune response was observed in the immunotherapy group. Following subsequent doses of MIP, decrease in the inflammatoryresponseandincreaseintheimmunosuppressiveresponsewasobserved,whichresultedintheimprovement oflungpathology. Conclusion:MIPimmunotherapyisavaluableadjuncttochemotherapyfortuberculosis.Aerosolrouteofimmunotherapy canplayacrucialroleforinducingimmediatelocalimmuneresponseinthelung. Citation: Gupta A, Ahmad FJ, Ahmad F, Gupta UD, Natarajan M, et al. (2012) Efficacy of Mycobacterium indicus pranii Immunotherapy as an Adjunct to ChemotherapyforTuberculosisandUnderlyingImmuneResponsesintheLung.PLoS