Enhanced Disease Susceptibility 1 and Salicylic Acid Act Redundantly to Regulate Resistance Gene-Mediated Signaling 英文参考文献.docVIP

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Enhanced Disease Susceptibility 1 and Salicylic Acid Act Redundantly to Regulate Resistance Gene-Mediated Signaling 英文参考文献.doc

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Enhanced Disease Susceptibility 1 and Salicylic Acid Act Redundantly to Regulate Resistance Gene-Mediated Signaling 英文参考文献

EnhancedDiseaseSusceptibility1andSalicylicAcidAct RedundantlytoRegulateResistanceGene-Mediated Signaling SrivathsaC.Venugopal1¤a,Rae-DongJeong1,MihirK.Mandal1,ShifengZhu1,A.C.Chandra-Shekara1¤b, YeXia1,MatthewHersh2,ArnoldJ.Stromberg2,DuRoyNavarre3,AardraKachroo1,PradeepKachroo1* 1DepartmentofPlantPathology,UniversityofKentucky,Lexington,Kentucky,UnitedStatesofAmerica,2DepartmentofStatistics,UniversityofKentucky,Lexington, Kentucky,UnitedStatesofAmerica,3UnitedStatesDepartmentofAgriculture–AgriculturalResearchService,WashingtonStateUniversity,Prosser,Washington,United StatesofAmerica Abstract Resistance (R) protein–associated pathways are well known to participate in defense against a variety of microbial pathogens. Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility1(EDS1),non–race-specificdiseaseresistance1(NDR1),phytoalexindeficient4(PAD4),senescenceassociated gene101(SAG101),andEDS5,havebeenidentifiedascomponentsofresistancederivedfrommanyRproteins.Here,we show that EDS1 and SA fulfill redundant functions in defense signaling mediated by R proteins, which were thought to function independent of EDS1 and/or SA. Simultaneous mutations in EDS1 and the SA–synthesizing enzyme SID2 compromisedhypersensitiveresponseand/orresistancemediatedbyRproteinsthatcontaincoiledcoildomainsattheirN- terminal ends. Furthermore, the expression of R genes and the associated defense signaling induced in response to a reductioninthelevelofoleicacidwerealsosuppressedbycompromisingSAbiosynthesisintheeds1mutantbackground. ThefunctionalredundancywithSAwasspecifictoEDS1.Resultspresentedhereredefineourunderstandingoftherolesof EDS1andSAinplantdefense. Citation:VenugopalSC,JeongR-D,MandalMK,ZhuS,Chandra-ShekaraAC,etal.(2009)EnhancedDiseaseSusceptibility1andSalicylicAcidActRedundantlyto RegulateResistanceGene-MediatedSignaling.PLoSGenet5(7):e1000545.doi:10.1371/journal.pgen.1000545 Editor:GregoryP.Copenhaver,TheUniversityofNorth