ENZO A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions 英文参考文献.docVIP
- 1、本文档共10页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
ENZO A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions 英文参考文献
ENZO:AWebToolforDerivationandEvaluationof
KineticModelsofEnzymeCatalyzedReactions
Stasˇ Bevc1,2,JanezKonc1,JureStojan3,MilanHodosˇcˇek1,MatejPenca1,MatejPraprotnik1,Dusˇanka
Janezˇicˇ1,2
*
1NationalInstituteofChemistry,Ljubljana,Slovenia,2UniversityofPrimorska,FacultyofMathematics,NaturalSciencesandInformationTechnologies,Koper,Slovenia,
3UniversityofLjubljana,MedicalFaculty,Ljubljana,Slovenia
Abstract
We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed
reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction
scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the
coefficientsofdifferentialequationstoexperimentallyobservedtimecoursecurves.ENZOallowsrapidevaluationofrival
reactionschemesandcanbeusedforroutinetestsinenzymekinetics.Itisfreelyavailableasawebtool,athttp://enzo.
cmm.ki.si.
Citation:BevcS,KoncJ,StojanJ,Hodosˇcˇek M,PencaM,etal.(2011)ENZO:AWebToolforDerivationandEvaluationofKineticModelsofEnzymeCatalyzed
Reactions.PLoSONE6(7):e22265.doi:10.1371/journal.pone.0022265
Editor:MatthewBogyo,StanfordUniversity,UnitedStatesofAmerica
ReceivedFebruary9,2011;AcceptedJune21,2011;PublishedJuly19,2011
Copyright:?2011Bevcetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted
use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:FinancialsupportwasprovidedbygrantsP1-0002,P1-0170,J1-2281,J1-2282oftheMinistryofHigherEducation,Science,andTechnologyofSlovenia
andtheSlovenianResearchAgency.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist.
*E-mail:dusa@cmm.ki.si
Introduction
dE=dt~k0?E??S?z(k1zk2)?ES?
dES=dt~k0?E??S?{(k1zk2)?ES?
dS=dt~{k0?E??S?zk1?ES?
dP=dt~k2?E
您可能关注的文档
- Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors 英文参考文献.doc
- Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons 英文参考文献.doc
- Endogenous Opioids in Wound-Site Neutrophils of Sternotomy Patients 英文参考文献.doc
- Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogens 英文参考文献.doc
- Endogenous Human Brain Dynamics Recover Slowly Following Cognitive Effort 英文参考文献.doc
- Endogenous PTH Deficiency Impairs Fracture Healing and Impedes the Fracture-Healing Efficacy of Exogenous PTH(1-34) 英文参考文献.doc
- Endogenous Morphine Levels Are Increased in Sepsis A Partial Implication of Neutrophils 英文参考文献.doc
- Endogenous Hepatitis C Virus Homolog Fragments in European Rabbit and Hare Genomes Replicate in Cell Culture 英文参考文献.doc
- Endogenous VEGF Is Required for Visual Function Evidence for a Survival Role on Müller Cells and Photoreceptors 英文参考文献.doc
- Endogenous Viral Elements in Animal Genomes 英文参考文献.doc
文档评论(0)