Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract 英文参考文献.docVIP

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Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract 英文参考文献.doc

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Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract 英文参考文献

FattyAcid-andCholesterolTransporterProtein ExpressionalongtheHumanIntestinalTract ChristiaanJ.Masson1,JogchumPlat1,RonaldP.Mensink1,AndrzejNamiot2,WojciechKisielewski3, ZbigniewNamiot4,JoachimFu¨llekrug5,RobertEhehalt5,JanF.C.Glatz6,MauriceM.A.L.Pelsers7* 1Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands, 2DepartmentofHumanAnatomy,MedicalUniversityofBialystok,Bialystok,Poland,3DepartmentofClinicalPathomorphology,MedicalUniversityofBialystok,Bialystok, Poland, 4Department of Physiology, Medical University ofBialystok,Bialystok,Poland, 5Department of Gastroenterology, University HospitalHeidelberg, Heidelberg, Germany, 6Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+, Maastricht, The Netherlands, 7DepartmentofClinicalChemistry,MaastrichtUniversityMedicalCentre+,Maastricht,TheNetherlands Abstract Background: Protein distribution profiles along the human intestinal tract of transporters involved in the absorption of cholesterolandlong-chainfattyacids(LCFA)havebeenscarcelyevaluated. Methodology/PrincipalFindings:Inpost-mortemsamplesfrom11subjects,intestinaltransporterdistributionprofileswere determined via Western Blot. Differences in transporter protein levels were statistically tested using ANOVA and Tukey’s PostHoccomparisons.Levelsinallsegmentswereexpressedrelativetothoseinduodenum.ExceptforABCG5andFATP4, levels(mean6SEM)werethehighestintheileum.ForABCA1,ileallevels(1.8060.26)differedsignificantlyfromthosein duodenum(P=0.049)andproximalcolon(0.9260.14;P=0.029).ABCG8levelsinileum(1.9160.30)differedfromthosein duodenum(P=0.041)anddistalcolon(0.8460.22;P=0.010)andjejunum(1.6460.26)tendedtobehigherthandistalcolon (0.8460.22; P=0.087). Ileal NPC1L1 levels (2.5660.51) differed from duodenum levels (P=0.019) and from distal colon (1.0960.22;P=0.030).Therewasalsoatrend(P=0.098)forhigherjejunal(2.2360.37)tha