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Genome-Scale Computational Biology and Bioinformatics in Australia 英文参考文献.doc

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Genome-Scale Computational Biology and Bioinformatics in Australia 英文参考文献

Perspective Genome-ScaleComputationalBiologyand BioinformaticsinAustralia MarkA.Ragan1,2,3*,TimLittlejohn4,BruceRoss5 1AustralianResearchCouncilCentreofExcellenceinBioinformatics,2InstituteforMolecularBioscience,TheUniversityofQueensland,Brisbane,Australia,3Schoolof InformationTechnologyandElectricalEngineering,TheUniversityofQueensland,Brisbane,Australia,4IBMAustralia,5MicrosoftAustralia Introduction Medicine,andRIKENGenomicSciences Center. friendlyportals,nodesinmajorcities,and a national training program. University Australia enjoys a high international reputation for research in experimental Building on strength in underlying biological and biomedical research, Aus- tralia was more proactive in functional genomics, i.e., transcriptomics, proteo- mics,andgenotype–phenotypeassociation studies. Expression-array platforms were installed at AGRF, the Commonwealth Scientific and Industrial Research Orga- nisation (CSIRO), and a number of universities and medical research insti- tutes. Leading statisticians in universities andCSIROtookonthehigh-dimensional problems posedbyexpression array data. The word proteome was coined in 1994 by Marc Wilkins, then a PhD student at TheUniversityofSydney[3].Proteomics developed around mass spectrometry and departments as a whole, as well as individual researchers from academia, genetics, molecular and cell biology, animal and plantsciences, biotechnology, the public sector, and private industry, subscribed to the ANGIS service, and it wasusedintensivelyformolecularbiology and bioinformatics education across Aus- tralia.ANGISwasafoundingmemberof Asia-PacificBioNet,formedin1998based ontheEMBNetmodelofdistributeddata and computational resources embedded with major user communities [1], and itself served as a model for the Canadian BioinformaticsResource.ABioMirrorsite wasestablishedattheAustralianNational University(ANU)incoordinationwiththe AustralianPartnershipinAdvancedCom- puting (APAC) to provide data, but was notintende